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Fecal calprotectin adds most to discrimination between pediatric patients with and without inflammatory bowel disease

Fecal Calprotectin Is Best Marker for Discriminating Pediatric IBD

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Blood markers, fecal calprotectin aid discrimination between pediatric patients with, without IBD
Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval

Studies Used for FDA Approval of Device Changes Often Low Quality

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And, efficacy of drugs granted accelerated approval often confirmed only years after approval
For rodents with diabetes

Hyperglycemia May Cause Caries but Not Periodontal Disease

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Findings in rodent models of type 1 and type 2 diabetes
Heterozygous HTRA1 mutations may play a role in familial cerebral small vessel disease

HTRA1 Mutations Tied to Cerebral Small Vessel Disease

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Correlation seen between mutations and MRI brain findings
There is a non-linear association between caloric load and reward

Taste, Calories Affect Metabolic Response to Sugared Beverages

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Metabolic responses up for lower calorie beverages, and when sweetness is proportional to caloric load
For humans and mice

Disruption of NAD Synthesis Tied to Congenital Malformations

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Patients with congenital mutations have lower levels of circulating nicotinamide adenine dinucleotide
A biomarker-based model provides a new tool for the prediction of cardiovascular death in patients with stable coronary heart disease

New Model Predicts Mortality in Stable Coronary Heart Disease

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Model uses age, biomarkers, clinical variables to predict cardiovascular death
Sleep-disordered breathing is associated with cognitive deficits

Sleep-Disordered Breathing Linked to Cognitive Dysfunction

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Hypoxemia and sleepiness associated with cognitive deficits, with strongest effect in APOE-ε4 carriers
Diabetes in infancy has different characteristics depending on mutation subtype

Characteristics of Diabetes in Infancy Explored

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Overall frequency of diabetic ketoacidosis 66.2 percent; odds increase with age at diagnosis
For patients newly diagnosed with type 1 diabetes

Peptide Immunotx Well Tolerated in New-Onset Type 1 Diabetes

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No decline in C-peptide with peptide immunotherapy; no change in insulin use over 12 months