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Researchers have identified a novel mechanism of glucose regulation of β-cell function and growth by repressing stress-induced microRNA-708

MicroRNA-708 Overexpression Suppresses β-Cell Proliferation

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Low glucose induction of miR-708 blocked by treatment with chemical chaperone 4-phenylbutyrate
Key stakeholders and physicians discussed electronic health record usability and optimization in the American Medical Association Running Your Practice Community.

Key Stakeholders Discuss How to Make EHRs More Usable

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Stakeholders, physicians discuss EHR usability and optimization, rules for releasing test results
A novel gene expression profiling diffuse large B-cell lymphoma classifier

Gene Expression Assay Classifies Diffuse Large B-Cell Lymphoma

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Assay assesses expression of 21 markers, classifies most samples into expected subtype
Modifiable conditions

Conditions Tied to Clinician Dissatisfaction Are Modifiable

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Improving workplace satisfaction directly tied to reduced clinician burnout
In the first year of the Affordable Care Act

Uninsurance Down by One-Third for Cancer Diagnoses in 2014

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Significant decreases in uninsurance seen across all stages and sites assessed in first year of ACA
Serum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest

Tau May Predict Neurological Outcome After Cardiac Arrest

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Increased serum tau is associated with worse outcome six months after cardiac arrest
Overall survival for patients with melanoma brain metastases has improved significantly since 2000

Overall Survival Up for Melanoma Brain Metastases

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Median overall survival from time of diagnosis has increased from 7.5 to 22.7 months
For male patients with cirrhosis

Visceral Adipose Tissue Index IDs Risk of HCC in Cirrhosis

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High VATI is also linked to risk of HCC recurrence in males with HCC who underwent liver transplant
For patients with venous thromboembolism

No Increased Risks for DOAC Use Versus Warfarin in VTE

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Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism
Proton pump inhibitor use is associated with increased risk of first-time ischemic stroke and myocardial infarction

PPI Use Linked to Increased Risk of Ischemic Stroke, MI

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Risks of first-time stroke, myocardial infarction up especially for long-term users, at high doses