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About one-quarter of adults with chronic kidney disease of unknown cause or familial nephropathy or hypertension have diagnostic mutations

Diagnostic Mutations ID’d in Chronic Kidney Disease Patients

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Whole-exome sequencing identified diagnostic mutations, including PARN mutations, in two patients
A case of a 16-year-old presenting to the emergency department with acute intermittent porphyria is described in a case report published online Dec. 5 in Pediatrics.

Acute Intermittent Porphyria Described in Teen Girl

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Clinical picture seemed consistent with constipation, but hyponatremia did not fit with diagnosis
CVS Health's planned purchase of insurance giant Aetna

CVS-Aetna Merger Has Implications for Doctors’ Offices

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More health services will likely move out of doctors' offices to store-based providers
Implementation of state newborn screening policies for critical congenital heart disease is associated with a decrease in infant cardiac deaths

State Newborn Screening Policies Cut Infant Cardiac Deaths

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Significant drop in infant cardiac deaths between 2007 and 2013 in states with mandatory screening
Nivolumab treatment for non-small-cell lung cancer may induce successful depletion of HIV reservoir

Nivolumab May Induce Successful Depletion of HIV Reservoir

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Case report describes smoker with HIV infection receiving nivolumab for non-small-cell lung cancer
Oral microbiome composition is associated with the risk of esophageal adenocarcinoma and esophageal squamous cell carcinoma

Oral Microbiome Composition Linked to Esophageal Cancer Risk

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Periodontal pathogen Tannerella forsythia linked to increased risk of esophageal adenocarcinoma
In patients with sickle cell anemia

Ceruloplasmin ID’d As Marker of Kidney Disease in Sickle Cell

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Findings part of proteomic analysis of urine in patients with sickle cell disease
In rural areas

Spatial Variation in Psychosis Incidence in Rural Areas

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For first episodes of nonaffective, affective psychotic disorders, incidence varies between neighborhoods

November 2017 Briefing – Pathology

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for November 2017. This roundup includes the latest...
Females with anorexia nervosa have lower gut microbial diversity

Lower Microbial Diversity in the Gut in Anorexia Nervosa

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Alpha diversity lower in anorexia nervosa, obese participants versus other groups; highest for athletes