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Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer's disease

In Alzheimer’s, BACE1 Inhibition May Reverse Amyloid Deposition

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Sequential, increased deletion of BACE1 in adult AD mouse model reversed amyloid deposition
Women undergoing screening breast magnetic resonance imaging have higher biopsy rates and significantly lower cancer yield findings compared with screening mammography alone

Higher Biopsy Rates for Women Undergoing Screening Breast MRI

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Lower cancer yield compared to mammography alone for women with, without personal history of cancer
Very low-dose 222-nm UVC ultraviolet light can inactivate more than 95 percent of aerosolized H1N1 influenza virus

Low Dose-Rate Far-UVC Light Can Inactivate Influenza Virus

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Far-UVC at 222-nm light can inactivate aerosolized viruses; >95 percent of H1N1 influenza inactivated
The burden of surgical site infection after gastrointestinal surgery is greater for countries with low income as classified by the U.N. Human Development Index

GI Surgical Site Infections Higher in Low-Income Countries

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Infection risk highest in countries with low income, low Human Development Index
A model with four categories has been developed to stratify patients with symptomatic long bone metastases based on their expected survival

New Model Stratifies Patients With Long Bone Metastases

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Model includes four prognostic categories with clinical consequences to predict median survival
For hospitalized patients with heart failure with preserved ejection fraction

Poor Outcomes With Systolic BP Below 120 mm Hg in HFpEF

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Increased risk of heart failure readmission at 30 days; of mortality, combined end point at 30 days, one year
Lipoproteins and lipids are similarly associated with risk of myocardial infarction and ischemic stroke but not intracerebral hemorrhage

Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke

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No association with ICH; within HDL, cholesterol inversely and triglyceride positively linked to MI
Four best practices outlined that can help prevent health care cyberattacks

Four Best Practices Outlined to Prevent Health Care Cyberattacks

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Health care execs should ID potential inefficiencies in cybersecurity, ensure systems backed up
Higher concentrations of perfluoroalkyl substances are associated with greater weight regain in a diet-induced weight-loss setting

Perfluoroalkyl Substances Linked to Greater Weight Regain

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Higher baseline levels of PFAS tied to greater weight regain in weight-loss setting, especially for women
The therapeutic significance of losartan in Marfan syndrome may lie in its ability to activate protective endothelial function

Losartan May Improve Endothelial Function in Marfan Syndrome

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Therapeutic importance may be increased in endothelial nitric oxide release, not ATR1 inhibition