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Despite low-level evidence

AAOS: Stem Cell Tx for Knee OA Costs About $5,000 Per Injection

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High cost, rapidly expanding use despite low-level evidence; mean marketed clinical efficacy of 82.2%
A single prostate-specific antigen screening is not associated with a significant difference in prostate cancer mortality after follow-up of 10 years

Single PSA Screening Doesn’t Cut Prostate Cancer Mortality

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But screening is associated with increased detection of low-risk prostate cancer
Fecal levels of volatile organic compounds are associated with response to dietary intervention in patients with irritable bowel syndrome

Volatile Organic Compounds in Feces Tied to Diet Response

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In IBS, fecal VOC profiling may be useful for predicting responses to dietary interventions
Compared with underrepresented minorities

Higher Positive Cardiomyopathy Genetic Detection Rates for Whites

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Higher positive detection rate and lower rate of inconclusive results vs. underrepresented minorities
There is little evidence for the clinical validity or utility of circulating tumor DNA assays for solid tumors

Limited Evidence for Clinical Validity, Utility of ctDNA

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No evidence for circulating tumor DNA assays in early-stage cancer, residual disease detection
Adolescents smoking electronic-cigarettes only have significantly higher excretion of volatile organic chemical compounds than non-smokers

Excretion of Volatile Organic Compounds Up in Teen E-Smokers

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Excretion of metabolites of acrylonitrile, acrolein, propylene oxide, acrylamide, crotonaldehyde up
High fish intake is associated with reduced risk of multiple sclerosis

AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis

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Two tag SNPs in fatty acid desaturase gene 2 independently linked to reduced risk of MS
Calcium supplements

Calcium ± Vit D Supplements Up Risk of Colon Adenomas, Polyps

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Late effect findings of sessile serrated adenomas, polyps in those taking calcium with/without vitamin D
Reclassification of diabetes into subgroups shows differing courses of disease progression and risk of diabetic complications

Researchers ID Five Distinct Adult-Onset Diabetes Subgroups

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These clusters show differing disease progression and risk of diabetic complications
Retinopathy is associated with accelerated rates of 20-year cognitive decline

Retinopathy Associated With Accelerated Cognitive Decline

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20-year cognitive change is greater with moderate-to-severe retinopathy than no retinopathy