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Higher concentrations of perfluoroalkyl substances are associated with greater weight regain in a diet-induced weight-loss setting

Perfluoroalkyl Substances Linked to Greater Weight Regain

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Higher baseline levels of PFAS tied to greater weight regain in weight-loss setting, especially for women
The therapeutic significance of losartan in Marfan syndrome may lie in its ability to activate protective endothelial function

Losartan May Improve Endothelial Function in Marfan Syndrome

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Therapeutic importance may be increased in endothelial nitric oxide release, not ATR1 inhibition
The U.S. Preventive Services Task Force recommends against screening for ovarian cancer in asymptomatic women. These findings form the basis of a final recommendation statement published in the Feb. 13 issue of the Journal of the American Medical Association.

USPSTF Recommends Against Ovarian Cancer Screening

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Among asymptomatic women, harms of screening for ovarian cancer outweigh potential benefits
Use of endoscopic ultrasound for rectal cancer staging is associated with higher use of neoadjuvant chemoradiation but no significant improvement in overall survival

Ultrasound for Rectal Cancer Staging Tied to More Chemoradiation

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But no significant improvement in overall survival compared with CT of the abdomen and pelvis only
Almost half of clinical trials for prostate cancer use criteria that disproportionately exclude black men

Criteria for Prostate Cancer Trials Disproportionately Exclude Blacks

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Trials sponsored by academic investigators, cooperative groups more likely to use these criteria
For infants born at a gestational age of less than 28 weeks

Low Postnatal Levels of Arachidonic Acid Linked to ROP

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Evaluating arachidonic acid and gestational age identifies ROP with a sensitivity >90 percent
From 1999 to 2015 there was a small reduction in the rate of sudden unexpected infant death

Cause of Sudden Unexpected Infant Deaths Shifts in the U.S.

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Decrease in SIDS, but spike in suffocation, strangulation; minimal decrease in overall rate
Congenital heart disease is associated with increased risk of dementia in adults

Premature Dementia Risk May Be Up in Survivors of Heart Defects

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Increased risk of dementia compared with general population, especially for early-onset dementia
Among U.S. adults with diabetes

Mortality Up in Diabetes With Low eGFR, No Albuminuria

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Mortality rates increasing among those with albumin-to-creatinine ratio <30 mg/g and low eGFR
Electronic health records are not sufficient to ensure success in value-based care

EHRs Not Sufficient to Ensure Success in Value-Based Care

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EHRs do not necessarily capture information needed; interoperability is poor, analytics are incomplete