Increased Flexibility Seen in Preapproval Evidence for New Drugs
Twenty-eight percent of trials used historical, external, or other control; nearly half used surrogate measure as a primary end point
mRNA-1273 Induces Stronger Response Than BNT162b2 for Immunosuppressed
Findings seen in immunosuppressed patients with rheumatic and musculoskeletal diseases, solid organ transplant recipients
Menopause Symptoms Correlate With Temporomandibular Disorder Pain
Correlation stronger in the late menopausal transition than other time points
Intervention Can Cut Risk for Mobility Disability in Seniors
Reduced incidence of mobility disability seen in older adults with physical frailty and sarcopenia receiving multicomponent intervention
TXA Seems Safe for Surgery in High-Risk Patients With IT Hip Fracture
No increased risk for mortality or thromboembolic complications seen with use of tranexamic acid among high-risk patients, entire cohort
PFAS, Phthalate Biomarkers Linked to Bone Mineral Density in Teens
Each doubling of serum perfluorooctanoate, overall PFAS/phthalate mixture linked to lower areal BMD in male adolescents
Mailed At-Home Disposal Kits Up Opioid Disposal Rates
Mailed kits are a potential low-cost, scalable solution, the authors say
AI Model Predicts Response to Spinal Cord Stimulation for Chronic Pain
Combined unsupervised (clustering), supervised (classification) machine learning technique used to develop predictive model
30.0 Million People of All Ages Uninsured in U.S. in 2021
For adults aged 18 to 64 years, 13.5 percent were uninsured, 21.7 percent had public coverage, 66.6 percent had private coverage
Polygenic Risk Score for OA Predicts Risk for Hip, Knee Replacement
Participants with high PRS had increased risk for joint replacement; stronger association seen with hip replacement for women versus men
