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The diagnosis and management of polycystic ovary syndrome is discussed in a case vignette published online July 6 in The New England Journal of Medicine.

Case Vignette Addresses Diagnosis, Management of PCOS

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Treatment decisions should be informed by patient priorities -- in this case hirsutism, irregular menses
Neratinib and veliparib-carboplatin appear to be effective in women with specific subtypes of breast cancer

Neratinib Active in HER2-Positive, HR-Negative Breast Cancer

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And higher pathologic complete response for veliparib-carboplatin in triple-negative breast cancer
Only about half of trials registered at ClinicalTrials.gov are listed in the largest data-sharing repository

Many Clinical Trials Are Not Listed in Data-Sharing Repository

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Fifty-three percent of randomized clinical trials were listed at Clinical Study Data Request website
Women with a history of cervical intraepithelial neoplasia 2 or 3 have increased risks of subsequent development of anal

Risk of Noncervical Anogenital Cancer Up With History of CIN2/3

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Women with history of CIN2/3 have increased long-term risk of anal, vulvar, vaginal cancers
The magnitude of the association between a multilocus genetic risk score for body mass index and BMI is larger for individuals born in later birth cohorts

Genetic Risk Score Impact on BMI Varies Across Birth Cohorts

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Larger magnitude of association between genetic risk score for BMI and BMI in later birth cohorts
A mindful self-compassion program can reduce depression

Mindful Self-Compassion Program Beneficial in Diabetes

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Emotional and metabolic benefits with reductions in depression and glycated hemoglobin
In an experimental study

Anti-Anxiety Medication May Limit Empathetic Behavior

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Midazolam-treated rats show less helping behavior than those receiving saline or no injection
Limiting first trimester screening (FTS) by cell-free fetal (cff) DNA to only patients in certain risk categories may be a feasible cost-containing strategy

Two-Stage Screening Could Be Cost-Effective for Trisomy

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Cost-benefit analysis of hypothetical model based on implementation of cell-free fetal DNA
Patients with heterozygous familial hypercholesterolemia have a significantly increased risk for coronary heart disease and atherosclerotic cardiovascular disease

CVD Risks Way Up in Familial Hypercholesterolemia

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Clinician-patient discussions on guideline-supported therapies can be informed by data
A metabolomics signature can predict the transition from gestational diabetes mellitus to type 2 diabetes

Metabolomics Signature Can Predict GDM to T2DM Transition

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Metabolomics with baseline fasting plasma could predict transition from gestational diabetes to T2DM