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A single nucleotide variant in the FTO obesity locus disrupts a conserved motif

Role of SNP Variant in FTO Explored in Obesity

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Study identifies mechanistic basis for the strongest genetic association with obesity
Lumbar spine bone mineral density increases fracture risk among women with lower lumbar spine T-score than femoral neck T-score

Lumbar Spine BMD Ups Fx Risk in Women With Discordant T-Scores

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Lower T-score for lumbar spine than femoral neck increases fracture risk, particularly in older women
Most lice populations have point mutations that are linked to pyrethroid resistance

Most Lice Populations Show Resistance to Pyrethroids

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104 of 109 samples from 30 states were 100 percent resistant in three point mutations
The U.S. Preventive Services Task Force (USPSTF) has found no net benefit for chronic obstructive pulmonary disease screening in asymptomatic adults and consequently recommends against screening. These findings form the basis of a draft recommendation statement published online Aug. 17 by the USPSTF.

USPSTF Draft Recommendation Urges Against COPD Screening

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Grade D statement recommends against routine screening for asymptomatic adults
Patients at greatest risk for an unplanned hospital readmission include those with chronic cardiovascular and pulmonary diseases

Risk Factors Can ID Patients More Likely to Be Readmitted

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Friday discharge, existing chronic diseases, high number of ER visits are predictors
For overweight or obese patients with type 2 diabetes

Liraglutide Linked to Weight Loss Over 56 Weeks in T2DM

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More weight loss for 3.0 mg liraglutide versus placebo among overweight/obese with type 2 diabetes
New violations by the maker of medical scopes recently linked to deadly infections in patients have been discovered by the U.S. Food and Drug Administration.

FDA Reveals More Violations by Medical Scope Maker

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Infections in patients who underwent procedures with Olympus scopes in 2012 went unreported
An electronic medical record-based care pathway improves treatment of cellulitis

EMR Care Pathway Aids Treatment of Cellulitis

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Antibiotic use, pharmacy costs, and length of stay cut without affecting readmissions
The diabetes drug metformin changes metabolic profiles of three metabolites that may lower LDL cholesterol

Metabolic Changes With Metformin May Lower LDL-C

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Possible metabolic mechanism includes activation of AMPK, FADS suppression
An approach for classifying pain severity developed by the Washington Group on Disability Statistics is effective for assessing self-reported pain among U.S. adults

Classification Details Pain Prevalence Among U.S. Adults

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6.4 percent of adults classified as having highest level of pain, based on persistence, bothersomeness