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De novo KCNB1 missense and loss-of-function variants are associated with neurodevelopmental disorders

Phenotype Varies for Presumed Pathogenic Variants in KCNB1

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De novo mutations in KCNB1 associated with variable neurodevelopmental disorder
Adoption of specialty access standards has not improved access to specialists

Specialist Access No Better With Adoption of Access Standards

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No notable improvement in timely access to specialty services following implementation of standards
Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval

Studies Used for FDA Approval of Device Changes Often Low Quality

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And, efficacy of drugs granted accelerated approval often confirmed only years after approval
Zika virus infection is associated with increased incidence of neurological syndromes

Diverse Spectrum of Neurologic Syndromes Seen With Zika

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Increase in admissions for Guillain-Barré syndrome, encephalitis compared with before outbreak
Intraindividual variability of reaction time is independently associated with mortality

Intraindividual Variability in Reaction Time Tied to Mortality

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Independent link identified, which changed very little after excluding incident dementia cases
There is a strong relationship between high on-clopidogrel platelet reactivity and two-year ischemic and bleeding outcomes after drug-eluting stent implantation

High Platelet Reactivity Tied to Ischemic, Bleeding Outcomes

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Findings based on two-year follow-up after drug-eluting stent implantation
Statin prescribing is considerable among nursing home residents

Statin Use Among Nursing Home Residents Varies Significantly

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Between-physician variability accounted for 9.1 percent of unexplained variation in statin use
In 2015

Rates of Active, Current Epilepsy in U.S. Adults Rising

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Variation in estimated number of people with active epilepsy, from 5,900 in Wyoming to 427,700 in Calif.
From 2004 to 2014 there was an increase in annual admissions in France for children with unintentional cannabis intoxication

Cannabis Intoxication Admissions in Children Up in France

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Increase in annual admissions for children from 2004 to 2014; 71 percent of patients were ≤18 months
The risk of arterial thromboembolism is increased in the short term among patients with incident cancer

Short-Term Risk of Arterial Embolism Up in Cancer Patients

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Increased risk of arterial thromboembolism, MI, ischemic stroke for cancer patients