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For patients with progressive multifocal leukoencephalopathy

Caution for PLEX in Progressive Multifocal Leukoencephalopathy

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Plasma exchange not linked to PML immune reconstitution inflammatory syndrome latency
Sub-anesthetic ketamine infusions are associated with improved short-term pain relief for migraine and other intractable headache

ASA: Ketamine Infusions May Relieve Pain in Migraine

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Least pain on day 4, achieved at mean ketamine rates of 30.8±3.6 mg/hr less than maximum dose
The strongest evidence for benefit of cannabinoids in children is for chemotherapy-induced nausea and vomiting

Limited Evidence of Benefit for Medical Cannabinoids in Children

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Strongest evidence for benefit in chemo-induced nausea, vomiting; other uses need more evidence
Smoking may modify a previously reported genetic association with Parkinson's disease

Smoking Alters Genetic Relationship with Parkinson’s

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Smoking, HLA-DRB1 may be involved in common pathways, possibly neuroinflammation
A joint effort between students at Warren Alpert Medical School of Brown University and Rhode Island School of Design is training future physicians in design thinking to help identify and repair health system issues that contribute to physician burnout

Design Thinking Enables Med Students to Solve Challenges

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Partnership with design students focuses on innovative solutions to health system issues
The U.S. Centers for Disease Control and Prevention has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection

CDC Updates Zika Guidance for Infant Care

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Recommendations include evaluation and management of infants with possible infection
Clinicians' job satisfaction is associated with improved burnout scores and reduced intention to leave their practices

Clinician Job Satisfaction Linked to Improved Burnout Scores

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Reduced intention to leave practice for clinicians who report increased job satisfaction during follow-up
Intravenous (IV) hydromorphone is less effective than IV prochlorperazine plus diphenhydramine for acute migraine treatment in the emergency department

IV Prochlorperazine Beats IV Hydromorphone for Migraine

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IV hydromorphone much less effective for migraine treatment in the emergency department
Transition from a condition-specific to a hospital-wide readmission measure would result in a modest increase in the number of hospitals eligible for readmission penalties and would substantially increase penalties for safety-net hospitals

More Penalties With Hospital-Wide Readmission Measure

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Increase in number of hospitals eligible for penalties, in penalty disparity for safety-net, other hospitals
Women and minorities undergoing percutaneous coronary intervention with everolimus-eluting stents have a risk of major adverse cardiac events that is similar to that of white men

MACE Risk Similar for White Men, Women, Minorities After PCI

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But women and minorities have higher adjusted risk of death/MI after PCI with everolimus-eluting stent