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Trials to evaluate drugs or devices used to treat chronic medical conditions that are published early in the chain of evidence often show an exaggerated treatment effect compared with subsequent trials

Early Studies Often Show Exaggerated Treatment Effect

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Findings based on assessment of trials evaluating drugs, devices to treat chronic medical conditions
In a position paper published online Feb. 27 in the Annals of Internal Medicine

Recommendations for Optimizing Hidden Curriculum in Medicine

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Clinical learning environment should be optimized by ensuring what is taught in classroom is modeled
Understanding nonadherence in patients and encouraging a change in attitude toward patients and their medication can improve medication adherence

Understanding Rx Nonadherence Can Improve Adherence

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Changing attitudes toward patients and their medication adherence can improve adherence
Among patients who opt for active surveillance of small renal masses

Growth Rates of Small Renal Masses Highly Variable Early On

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Not reliable predictor of adverse outcomes in those under active surveillance; less variability over time
Children with chronic kidney disease may have deficits in global and domain-specific cognition

Cognition Deficits Seen in Children With Chronic Kidney Disease

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Children with less severe CKD and kidney transplant had higher full-scale IQ than those on dialysis
Artificial intelligence

Artificial Intelligence May Help Prevent Physician Burnout

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Many potential uses for AI, including improving searches and documentation, selecting treatment
The percentage of uninsured U.S. persons of all ages did not change significantly from 2016 to the first nine months of 2017

CDC: No Change in Percentage of Uninsured in U.S. From ’16 to ’17

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Increase in percentage of those aged younger than 65 years enrolled in high-deductible health plan
For adults with sepsis

No Evidence Use of SEP-1 Bundle Ups Survival in Sepsis

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Neither the sepsis management bundle nor its interventions improve survival for adults with sepsis
For older patients with concomitant chronic kidney disease and a new diagnosis of atrial fibrillation

Anticoagulants in Seniors With A-Fib, CKD Ups Stroke, ICH Risk

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Anticoagulants linked to increased risk of ischemic stroke and hemorrhage, but lower all-cause mortality
Burnout is prevalent among physicians

Burnout Found Prevalent Among Doctors in Single Health System

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Link between patient satisfaction and emotional exhaustion; also tied to odds of leaving organization