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Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval

Studies Used for FDA Approval of Device Changes Often Low Quality

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And, efficacy of drugs granted accelerated approval often confirmed only years after approval
Apathy is associated with mortality in nursing home patients

Apathy Tied to Mortality in Nursing Home Patients

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Mortality risk also increased for males, older patients
All-cause and cardiovascular disease mortality are reduced for U.S. adults with light and moderate alcohol intake

All-Cause, CVD Mortality Down With Light, Moderate Drinking

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Risk of mortality for all causes, cancer up for adults with heavy alcohol consumption, binge drinking
The risk of arterial thromboembolism is increased in the short term among patients with incident cancer

Short-Term Risk of Arterial Embolism Up in Cancer Patients

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Increased risk of arterial thromboembolism, MI, ischemic stroke for cancer patients
Cannabis may alleviate neuropathic pain

Review: Cannabis May Alleviate Neuropathic Pain

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Second review shows no benefit for plant-based cannabis preparation versus nonuse for PTSD
For patients with congenital heart disease and atrial arrhythmias

Most Common Arrhythmia: Intra-Atrial Re-Entrant Tachycardia

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Among those age ≥50 years, atrial fibrillation increased with age to surpass IART as most common
Statin prescribing is considerable among nursing home residents

Statin Use Among Nursing Home Residents Varies Significantly

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Between-physician variability accounted for 9.1 percent of unexplained variation in statin use
From 2009 to 2015 there was an increase in opioid overdose admissions requiring intensive care

ICU Admissions for Opioid Overdose Up From 2009 to 2015

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Average annual mortality rate was 7 percent, with increase to 10 percent in 2015
There is considerable variation in nonparticipation in diabetes self-management classes

Variation in Participation in Diabetes Self-Management Class

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Nonparticipation varies by race/ethnicity, education, health care coverage, county, time since diagnosis
In 2015

Rates of Active, Current Epilepsy in U.S. Adults Rising

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Variation in estimated number of people with active epilepsy, from 5,900 in Wyoming to 427,700 in Calif.