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Small molecular medicines can be printed precisely using organic vapor jets

Process Promising for On-Site Printing of Custom-Dosed Meds

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Printed films, original powders exhibit similar crystallographic order and chemistry
For patients with acute heart failure admitted to the emergency department

ER Risk Score Predicts 30-Day Mortality in Acute Heart Failure

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Risk score based on 13 independent risk factors has excellent discrimination and calibration
Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs

Commercialization of Generics Impacts Adverse Event Rates

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Adverse events up for generic users of losartan, valsartan, candesartan in month of commercialization
Many basic scientists and clinical researchers support somatic genome editing in adults for prevention of serious disease but not for human enhancement; they also believe the public should be consulted before any clinical application of germline gene editing proceeds

Scientists Support Genome Editing to Prevent Disease

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Majority of survey respondents support gene editing to treat diseases but not human enhancement
An analysis of whole-exome and RNA sequencing data reveals mutations

Insulinomas May Hold Key to Diabetes Drug Development

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Novel discovery of molecular pathways may reveal map to regenerate insulin-producing cells
Treatment with long-acting muscarinic antagonists plus long-acting β-agonists is associated with fewer exacerbation events in patients with chronic obstructive pulmonary disease

LAMA Plus LABA Tied to Fewer Exacerbations in Stable COPD

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Also might result in greater improvement in FEV1 than LABA plus corticosteroids
Nonvalvular atrial fibrillation patients who take non-vitamin K oral anticoagulants along with certain other medications are at increased risk for major bleeding

Anticoagulants With Other Drugs Raise Bleeding Risk in AF

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And antithrobotic medications linked to higher rate of hematuria-related events in older adults
The burden of overweight- and obesity-related cancer is high in the United States

Rate of Obesity-, Overweight-Related Cancers High in the U.S.

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40 percent of cancer diagnoses tied to extra weight; rate higher in older individuals, females
Many female physicians report feeling disadvantaged when negotiating contracts and feel that they are assessed for promotion using different criteria than those used for men

Pay Inequality, Work-Life Balance Top Concerns for Female Docs

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Despite challenges, 86 percent say they are likely to continue practicing as doctors for rest of career
For patients at high risk for breast cancer

Provider Advice Impacts Breast Cancer Prevention Decisions

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Worry, trust also affect choice on whether to use selective estrogen receptor modulators