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Hepatic fat accumulation may play a causal role in chronic liver disease

Hepatic Fat Accumulation May Have Causal Role in Liver Disease

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Impact of genetic variants on liver damage proportional to effect on hepatic fat accumulation
In the presence of complete deep core muscle weakness

Core Muscle Weakness Increases Spinal Loading, Back Injuries

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Deep core muscle weakness linked to increase in peak anterior shear loading on all lumbar vertebrae
Percutaneous and transcatheter patent foramen ovale (PFO) closure prevent recurrent stroke in adults with PFO and cryptogenic stroke

Closure of Patent Foramen Ovale Cuts Recurrent Stroke/TIA Risk

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Reviews demonstrate reduction in recurrent stroke risk after percutaneous transcatheter PFO closure
Improving adherence to healthy dietary patterns may help reduce the genetic association with weight gain

Adherence to Healthy Diet May Cut Effects of Genetics on Obesity

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Long-term, improved diet quality benefits weight control in those with high genetic risk of obesity
Transdermal estradiol plus intermittent micronized progesterone can prevent clinically significant depressive symptoms among euthymic perimenopausal and early postmenopausal women

Transdermal Estradiol May Help Prevent Depressive Symptoms

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Effects of TE, micronized progesterone seen in perimenopausal, early postmenopausal women
For community-dwelling older adults

Adherence to Mediterranean Diet Linked to Reduced Frailty

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Lower risk of incident frailty for community-dwelling older adults with greater adherence to the diet
For young adults without known risk factors

HIV Screening Most Optimal at 25 Years of Age If No Risk Factors

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Simulation favors screening at 25 for adolescents, young adults without identifiable HIV risk factors
A long-term physical activity program is not associated with reduced risk of frailty among community-dwelling older adults with functional limitations

Physical Activity Doesn’t Seem to Reduce Risk of Frailty in Elderly

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Baseline frailty didn't modify effect of physical activity on reducing major mobility disability
Higher-intensity end-of-life care may be driven by financial incentives present in fee-for-service Medicare but not in the Veteran Affairs integrated system

Intense End-of-Life Care Found to Be Less Likely for VA Patients

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Authors say results have important implications for the future of VA care, Medicare policy
Assessing change in the CHA2DS2-VASc score over time is more predictive of ischemic stroke in patients with atrial fibrillation than the baseline score

Follow-Up Delta CHA2DS2-VASc Score Better Predicts CVA in A-Fib

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CHA2DS2-VASc score not static; most a-fib patients develop new risk factor before ischemic stroke