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Many providers stopped initiating opioid therapy from July 2012 to December 2017

Opioid Prescriptions Dropped for New Users From 2012 to 2017

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Decline seen in number of providers initiating opioid therapy in any patients who have not used opioids
There has been a steady rise in mood disorder and suicide-related outcomes among individuals born from the early 1980s to the late 1990s

Mental Health Issues Have Risen in Teens, Young Adults

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Rates of depressive episodes, serious psychological distress, suicide-related outcomes have increased
Recommendations have been developed for use of polymyxins

Guidelines Developed for Polymyxin Antibiotic Use

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Polymyxin B recommended for routine use in invasive infections; colistin preferred for lower UTI
Testosterone therapy can prevent progression to type 2 diabetes in men with prediabetes and hypogonadism

Testosterone Therapy in Hypogonadism Can Prevent Progression to T2DM

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Men with prediabetes, hypogonadism achieved normal glucose regulation with TTh
Having affected first-degree

Having Affected Relatives Linked to Increased Alzheimer Risk

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Increased Alzheimer disease risk seen with having affected first-, second-, or third-degree relatives
Knee pain is not associated with daily walking levels in individuals with mild-to-moderate

Knee Pain Not Tied to Activity Levels in Knee Osteoarthritis

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Neither inverted KOOS-pain nor P4 pain scale tied to physical activity
Mortality attributed to dementia increased from 2000 to 2017

CDC: 2000 to 2017 Saw Increase in Mortality Due to Dementia

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Age-adjusted death rate was 66.7 deaths per 100,000 U.S. population in 2017
The 99th centile of high-sensitivity cardiac troponin I concentration is substantially higher in a hospital population than the manufacturer's recommended upper limit of normal

Troponin Assay Confusion May Cause Misdiagnosis of Acute MI

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Overall, 5.4 percent of 20,000 patients had high-sensitivity troponin I concentration >40 ng/L
For HIV-infected patients

One-Month Regimen Noninferior for Preventing HIV-Related TB

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One-month rifapentine, isoniazid noninferior to nine months of isoniazid alone
There is considerable concern regarding the potential negative impact that electronic cigarettes and other new products may have on ending all tobacco use and nicotine addiction

E-Cigarettes May Threaten Goal of Achieving Tobacco Endgame

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Concern increasing that use of newer tobacco products may catalyze transition to tobacco products, drugs