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Vaccination for influenza for multiple seasons is twice as effective in preventing severe influenza -- compared with non-severe influenza -- in older patients admitted to hospital

Repeated Flu Vaccinations Help Prevent Severe Infection

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Annual vaccination found to lessen flu severity, hospitalizations, and death among the elderly
The new adjuvanted herpes zoster subunit vaccine is cost-effective compared with the currently recommended live attenuated herpes zoster vaccine

Adjuvanted Shingles Subunit Vaccine Likely More Cost-Effective

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Less overall cost and more effective than live attenuated vaccine at all ages; generally a good value
Type 1 interferons may mediate pregnancy complications in the context of congenital Zika virus infection

Type 1 IFNs May Mediate Zika Pregnancy Complications

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After Zika virus infection, IFNAR signaling in conceptus inhibits development of placental labyrinth
Provider collaboration with local specialty pharmacies is associated with reduced delays in therapy and lower rates of direct-acting antiviral denial for patients with hepatitis C

Pharmacies Can Up Access to Direct-Acting Antivirals for Hep C

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Collaboration with local specialty pharmacy linked to reduced delays in therapy, lower rates of denial
For high school students

2005 to 2015 Saw Fewer High School Students Having Sex

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Significant drop in proportion of high school students who had ever had sexual intercourse nationwide
Hospitals that volunteered to be under financial incentives for more than a decade as part of the Premier Hospital Quality Incentive Demonstration do not have better process scores or lower mortality than hospitals where these incentives were implemented later under the Hospital Value-Based Purchasing program

For Hospitals, No Benefit for Early Adoption of Financial Incentives

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Hospitals with early adoption do not have better process scores, lower mortality than late adopters
Hematopoietic stem/progenitor cell-derived chimeric antigen receptor T-cells are capable of long-term engraftment in a model of HIV/AIDS

HSPC-Derived CAR T-Cells Capable of Lasting Engraftment

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Chimeric antigen receptor T-cells persisted more than 2 years without measurable toxicity in primate model

December 2017 Briefing – Infectious Disease

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Here are what the editors at HealthDay consider to be the most important developments in Infectious Disease for December 2017. This roundup includes the...
From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

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More than three-fold increase in percentage of adults using gabapentin and/or pregabalin
High-frequency psychosocial risk factors during adolescence have a lasting effect on the likelihood of engaging in HIV risk behaviors in adulthood

Psychosocial Risk in Teens Tied to Lasting HIV Vulnerability

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High-frequency psychosocial risk trajectory has lasting effect on HIV risk behaviors in adulthood