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Eli Lilly and Co. is seeking U.S. approval for emergency use of an experimental antibody therapy for COVID-19.

Company Seeks FDA Emergency Approval for COVID-19 Antibody Therapy

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Request based on partial clinical trial findings suggesting the drug reduces symptoms in mild or moderate COVID-19
Neurologic manifestations are common in COVID-19

Neurologic Manifestations Seen in Most Hospitalized With COVID-19

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Encephalopathy, seen in 31.8 percent of hospitalized patients, tied to worse functional outcome, mortality
Lopinavir-ritonavir is not associated with reductions in 28-day mortality or duration of hospital stay among patients admitted to the hospital with COVID-19

Lopinavir-Ritonavir No Benefit in Patients Admitted With COVID-19

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No reductions seen in 28-day mortality or duration of hospital stay in COVID-19 with lopinavir-ritonavir
Antibiotics are noninferior to appendectomy for treatment of appendicitis

ACS: Antibiotics Noninferior to Appendectomy for Appendicitis

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However, complications occurred more often in the antibiotics group than in the appendectomy group
Only 51 percent of Americans would get a COVID-19 vaccine

Poll: Only Half of Americans Would Try to Get COVID-19 Vaccine

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If enough people in the U.S. pass on vaccine, the nation may not be able to achieve herd immunity
Hydroxychloroquine administered for eight weeks as preexposure prophylaxis has no clinical benefit in hospital-based health care workers exposed to patients with COVID-19

Hydroxychloroquine Not Beneficial for SARS-CoV-2 Preexposure Prophylaxis

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No clinical benefit seen versus placebo for hospital-based health care workers exposed to patients with COVID-19
Among critically ill neonates and children

CLABSI Rates Have Remained Stable in Neonatal, Pediatric ICUs

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However, 2013 to 2018 saw decrease in population-based CAUTI rates, indwelling urinary catheter use
Fecal microbiota transplantation is effective for Clostridium difficile infection through six months and has a good safety profile

Fecal Transplant Safe, Effective for C. Difficile Through Six Months

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90 percent of those undergoing FMT had one-month cure; 4 percent had recurrence within six months
Pandemic-induced impairments in work and social functioning are strongly correlated with elevated depression and anxiety symptoms and with decreased psychological well-being

Pandemic-Induced Impairments in Work Impact Mental Health

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Impairments in work and social functioning strongly linked with elevated depression, anxiety symptoms
The 2018 to 2019 influenza vaccine effectiveness was about 40 to 60 percent for reducing pediatric influenza A-associated hospitalizations and emergency department visits

2018 to 2019 Vaccine Cut Influenza A-Linked Hospitalizations

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Influenza vaccine reduced pediatric influenza A-linked hospitalizations, ED visits by 40 to 60 percent