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The selective Hedgehog antagonist PF-04449913 seems safe and is tolerated in adults with myeloid malignancies

New Rx for Myeloid Malignancies Moves to Phase II Clinical Trials

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Phase I trial involving 47 patients identified maximum tolerated dose of 400 mg once daily
For patients with hepatocellular carcinoma

Not Resecting Ideal Candidates Ups Mortality in Liver Cancer

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For nonideal candidates, resection linked to improved outcomes versus some alternatives
In a position statement published online July 20 in the Journal of Clinical Oncology

ASCO Calls for Cancer Trials to Include More Seniors

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Older adults react differently to treatment, oncology group notes
Millions more Americans have affordable health insurance

Patients Report Improved Care Access, Better Health With ACA

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Gains seen in how many adults have insurance and a doctor, and say they are in better health
About 10 percent of cases where a drug does serious harm are not reported to the U.S. Food and Drug Administration within the required 15-day period

Delays Noted in the Reporting of Serious Patient Harms to FDA

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Analysis found roughly 10 percent of cases were filed after 15-day deadline passed
More than a third of colorectal cancers diagnosed in younger patients are caused by inherited gene mutations

35% of Colorectal Cancers in Patients Age ≤35 Are Genetic

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Study authors recommend that people diagnosed before age 35 get tested
Many young cancer patients -- especially females -- have limited awareness about options to preserve their fertility

Cancer Patients Lack Awareness of Fertility Preservation Options

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Almost one in three not told cancer treatment might affect future fertility
Eradication of Helicobacter pylori in asymptomatic adults is associated with a reduction in the incidence of gastric cancer

Review: Eradicating H. pylori Cuts Incidence of Gastric Cancer

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Reduction in the incidence of gastric cancer with tx of asymptomatic, otherwise healthy individuals
As a result of the increasing popularity of high-deductible health care plans

Expansion of High-Deductible Plans to Impact Physician Care

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Physicians must be able to balance provision of good clinical care with ability to limit costs
For patients with end-stage cancer

Chemotherapy Use Doesn’t Improve QOL Near Death

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No improvement in quality of life, even for patients with good baseline performance status