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A case of cryptococcal meningitis with false-negative cerebrospinal fluid culture results following receipt of capecitabine has been described in a case report published in the December issue of the Journal of Clinical Pharmacy and Therapeutics.

Antineoplastic Agent Obscures Diagnosis of Fungal Meningitis

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Cerebrospinal fluid culture results were negative following receipt of capecitabine
The rates of contraceptive provision for adolescents prescribed teratogens are low

Contraceptive Provision Rates Low for Teen Girls on Teratogens

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Contraceptive provision in only 28.6 percent of visits; provision more likely for white, older girls
Men with localized prostate cancer are more likely to survive if they have surgery rather than radiation therapy

Surgery May Beat Radiotherapy for Localized Prostate Cancer

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Analysis of 19 studies suggests surgery has an edge in survival
The efficacy of ovarian cancer screening is unclear

Longer Follow-Up Needed to Evaluate Ovarian CA Screening

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Significant reduction in mortality with multimodal screening when prevalent cases excluded
For patients with glioblastoma

Tumor-Treating Fields Prolong Survival in Glioblastoma

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Randomized trial terminated early based on benefit shown for TTFields added to maintenance chemo
There's been a sharp rise in the number of industry-funded clinical trials and a significant decline in those financed by the U.S. government in recent years

Industry Outpacing NIH in Funding Research

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Analysis finds studies paid for by private sector increasing, while U.S.-sponsored trials decline
Better screening and lifestyle changes have helped to reduce the prevalence of common cancers in many high-income countries

Uptake of ‘Western Lifestyle’ Tied to Rising Cancer Rates

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Lower-income countries have rising rates of same cancers common in high-income countries
About 20 percent of patients administered fresh frozen plasma (FFP) to reverse warfarin anticoagulation develop pulmonary complications

Dose-Linked Pulmonary Complications After FFP Infusion

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In warfarin reversal, highest risk with more than three units of fresh frozen plasma
A combination of immune-modulatory in situ gene therapy and intensity-modulated radiotherapy is highly effective in treating prostate cancer

‘Suicide Gene Therapy’ Plus Radiation Effective in Prostate CA

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Immunomodulatory in situ gene tx/IMRT with or without hormonal tx deemed feasible, safe
Neoadjuvant chemotherapy is less likely to benefit black women with breast cancer than those in other racial and ethnic groups

Early Chemo Less Likely to Help Black Breast Cancer Patients

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More research needed to explain why outcomes differ among black, Hispanic, and Asian women