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December 2016 Briefing – Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for December 2016. This roundup includes...
For patients undergoing autologous breast reconstruction

No Effect for BUP TAP Catheter on Chronic Pain After Breast Recon

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No difference in chronic postsurgical pain incidence for TAP catheter delivering bupivacaine, saline
The BodyFIX without wrap is suitable for clinical immobilization during radiotherapy

BodyFIX Without Wrap Works for Radiotherapy Immobilization

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Compared to two other immobilization devices, BodyFIX was preferred by staff
There is a direct correlation between the pretreatment serum uric acid level and tumor progression in patients with locally advanced nasopharyngeal carcinoma

Uric Acid May Mark Progression for Nasopharyngeal Cancer

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High pretreatment uric acid may be clinical biomarker for lung metastasis
A panel of 88 single nucleotide polymorphisms can predict breast cancer risk

Panel of 88 SNPs Predicts Breast CA Risk in Women at High Risk

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SNP88 is independent of Tyrer-Cuzick model; improved prediction when combined multiplicatively
African-American identity is associated with increased risk of triple-negative breast cancer among women with a prior diagnosis of benign breast disease

Triple-Negative Breast CA Risk Up for Blacks With Benign Breast Dz

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Increased risk of TNBC among African-American women with prior diagnosis of benign breast disease
For women undergoing wire-guided breast conserving surgery for nonpalpable breast lesions

Reoperation Risk for Nonpalpable Breast Lesions Higher for DCIS

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Reoperation rate low after wire-guided breast conserving sx, but higher for DCIS than invasive BC
The oral selective inhibitor of MAPK kinase 1 and 2

Selumetinib Active in Children With Neurofibromatosis Type 1

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Patients were able to receive selumetinib on long-term basis; maximum tolerated dose 25 mg/m²
Treatment with autologous chimeric antigen receptor-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 is associated with tumor regression in recurrent multifocal glioblastoma

Case Report: Adoptive T-Cell Tx Shows Promise in Glioblastoma

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Tumors regressed after intracranial infusions of T cells engineered to target tumor-associated antigen
Among U.S. adults

Iron Deficiency Anemia Ups Risk of Hearing Loss in U.S. Adults

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After adjustment for sex, adults with IDA have increased odds of SNHL, combined hearing loss