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Patients with severe neurotoxicity after infusion of CD19-targeted chimeric antigen receptor-modified T cells have evidence of endothelial activation

Neurotoxicity Characterized After Infusion of CD19 CAR-T Cells

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Patients with severe neurotoxicity have endothelial activation, increased BBB permeability
The Wisconsin Supreme Court is considering whether it will hear a case that will determine the fate of the state's $750

Court Considering Fate of Noneconomic Damages Cap

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Case would decide the fate of Wisconsin's $750,000 cap on noneconomic damages
The HSD3B1 (1245C) allele is associated with more rapid development of metastases in men with biochemically recurrent prostate cancer

Genetic Variant Tied to Prostate Cancer Outcomes

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Time to metastasis, length of survival vary by number of HSD3B1 (1245C) variant alleles
There is wide variation in thyroidectomy rates among Medicare beneficiaries nationally

Across U.S., Wide Variation Seen in Thyroidectomy Rates

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Rate per 100,000 Medicare beneficiaries ranges from 22 to 139, a 6.2-fold difference
Anecdotally

Physician Salaries Appear to Be Flat or Declining

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Lack of income growth felt by primary care and specialty physicians
A new risk-stratification tool is able to estimate mortality in patients with urothelial carcinoma of the bladder after cystectomy

New Tool IDs Mortality Risk After Bladder Cancer Surgery

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Tool incorporates the relative contribution of tumor stage, lymph node involvement
For HIV-infected men who have sex with men

HPV Vaccination After Lesion Treatment Is Likely Cost-Effective

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Adjuvant HPV vaccination could reduce anal cancer risk in HIV-infected men who have sex with men
Medical licensure application questions regarding mental health contribute to physicians' reluctance to seek help for mental health

Medical License Questions Sway Doctors’ Mental Health Help

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Asking only about current mental health may encourage help-seeking behavior
For asymptomatic adults with positive fecal blood test results

Patient, Provider Interventions May Up Colonoscopy Rates

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Patient navigators, provider reminders may improve colonoscopy rates after positive fecal test
Novel metrics have been developed to assess electronic health record use and are described in an opinion article published online Oct. 9 in the Annals of Internal Medicine.

Novel Metrics Suggested for Assessing EHR Use

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Metrics aim to provide insight into the clinician experience in light of impaired practice efficiency