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Males with BRCA mutations have increased incidence of malignant disease

Males With BRCA Mutations Have Increased Risk of Certain Cancers

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Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers
The estimated annual cost of drug-related morbidity and mortality resulting from nonoptimized medication therapy is more than half a trillion dollars in the United States

Nonoptimized Drug Therapy Costs More Than $500 Billion Annually

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After initial Rx use, average cost of individual having treatment failure, new medical problem over $2,000
Volumetric laser endomicroscopy users can identify regions of interest for potential Barrett's esophagus dysplasia with a high degree of agreement

Volumetric Laser Endomicroscopy Helps ID Barrett’s Regions

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High agreement among reviewers seen in 80 percent of quadrants
Transcription factors seem to operate across gene loci

TFs Operate Across Gene Loci Within Disease Phenotypes

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Epstein-Barr virus EBNA2 protein binds to multiple loci of genome, increasing risk of 7 serious diseases
Pembrolizumab is associated with significantly longer recurrence-free survival than placebo as adjuvant therapy for high-risk stage III melanoma

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

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Pembrolizumab linked to significantly longer recurrence-free survival at 15-month follow-up
In a position paper published online April 17 in the Annals of Internal Medicine

Recommendations Developed on Gender Equity in Medicine

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ACP supports equitable physician compensation based on comparable work at each stage of career
For metastatic non-small-cell lung cancer (NSCLC)

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

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And, nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden
Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors is associated with improved survival for patients with stage III colon cancer

Adherence to ACS Guidelines Linked to Survival in Colon Cancer

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Lower risk of death, improved disease-free survival for ACS guideline score of 5 to 6 versus 0 to 1
Negative affect that lingers is associated with worse physical health outcomes almost 10 years later

Negative Affect That Lingers Tied to Health 10 Years Later

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Higher levels of lingering negative affect linked to more chronic conditions, worse functional limitations
Heart failure is not associated with an increased risk of cancer

No Higher Cancer Risk Seen for Heart Failure Patients

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After a median 20 years of follow-up, heart failure not associated with cancer incidence