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Higher inpatient pain scores and postoperative opioid consumption are associated with persistent opioid use of up to six months among children and adolescents who have undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Persistent Post-Op Opioid Use in Young Cancer Patients Explored

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Higher inpatient pain scores linked to persistent use after major oncologic surgery for children, teens
Many countries are falling short on targets to reduce mortality from non-communicable diseases

Many Countries Failing on Non-Communicable Dz Death Targets

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For women and men, 35 and 30 countries expected to meet Sustainable Development Goal target 3.4
Symptoms of burnout and career choice regret are prevalent among U.S. resident physicians

Burnout, Career Choice Regret Prevalent in U.S. Residents

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Considerable variation according to specialty for both burnout symptoms, career choice regret
Physician-group accountable care organizations (ACOs) participating in the Medicare Shared Savings Program generated significantly more savings for Medicare that grew from 2012 to 2015 compared with hospital-integrated ACOs

Physician-Group ACOs Generate Medicare Savings

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Savings grow with longer participation and are significantly higher than hospital-integrated ACOs
From 2013 to 2016

In 2016, Proportion of Uninsured Americans Down to 10 Percent

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Larger reductions in uninsured rate in Medicaid expansion states, from 15.3 to 7.6 percent
Checkpoint blockade immunotherapy is associated with significant increases in overall survival in a real-world population of patients undergoing treatment for melanoma brain metastases

Novel Immunotherapy May Up Survival in Melanoma Brain Mets

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Findings in patients receiving checkpoint blockade immunotherapy for melanoma brain metastases
Among individuals undergoing hereditary cancer testing

Cancer-Related Gene Variations Frequently Reclassified

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24.9 percent of variants of uncertain significance were reclassified at a single commercial laboratory
A major non-profit advocacy group is asking that a large government trial comparing treatments for sepsis be shut down.

Critics Demand Stop to ‘Guinea Pig’ Sepsis Clinical Trial

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Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis
Currently

Most Breast Cancer Diagnoses Given Over the Phone

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This represents a reversal, with in-person diagnoses more common before 2006
There is variation in the net clinical benefit of anticoagulants based on variation in published atrial fibrillation stroke rates

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

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Benefit of warfarin anticoagulation varies with varying published stroke rates