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The U.S. Food and Drug Administration recently announced the approval of Daurismo (glasdegib) tablets for use in combination with a low dose of the chemotherapy cytarabine to treat newly diagnosed acute myeloid leukemia. The treatment is indicated for patients aged 75 years or older who have comorbidities that may prevent the use of intensive chemotherapy.

FDA Approves New Treatment for Acute Myeloid Leukemia

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Randomized clinical trial showed significant improvement in overall survival with Daurismo
Old age at onset of early rheumatoid arthritis is associated with more frequent bone erosions

Bone Erosions More Frequent With Old Age at Onset of Early RA

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Bone erosions more frequent in those older at early RA onset even if they had clinical remission
Arterial stiffness may predict dementia risk

Arterial Stiffness May Predict Dementia Risk

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Adjustment for subclinical brain disease markers did not reduce link between arterial stiffness, dementia
Women aged 75 years and older can still benefit from routine mammography

RSNA: Mammography Has Value in Women Age 75 or Older

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Cancer detection rate is 8.4/1,000 exams in older women; 98 percent of cancers surgically excised
Military patients whose primary care clinicians participated in a telementoring program

Pain Management Telementoring May Cut Opioid Prescribing

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Declines seen in annual prescriptions per patient, dose per patient, and number of opioid users
Frail acute myocardial infarction patients are less likely to undergo cardiac catheterization and have an increased risk for bleeding

Major Bleeding Up With Frailty in Acute MI Patients

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Increased risk for bleeding for those undergoing catheterization, not with conservative management
Older adults with untreated hearing loss have increased total health care costs and an increased risk for medical comorbidities

Health Care Costs, Use Up for Untreated Hearing Loss

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Risks also increased for medical comorbidities among older adults with untreated hearing loss
Few patients hospitalized for chronic obstructive pulmonary disorder receive pulmonary rehabilitation

Patients Hospitalized for COPD Rarely Receive Pulmonary Rehab

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Elderly, those living >10 miles from facility, those with lower SES less likely to receive pulmonary rehab
In the first six months of 2018

CDC: 8.8 Percent Uninsured in U.S. in First Half of 2018

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12.5 percent of adults aged 18-64 years and 4.4 percent of children aged 0-17 years uninsured
Both hospitalizations and deaths are increasing among Medicare recipients with liver cancer

Burden of Liver Cancer Rising in Medicare Patients

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Coexistence of other liver conditions tied to even higher risk for death, health care costs