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For young adults

Young Male Adults Have Lower Cancer Burden Than Women

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Incidence of all invasive cancers decreased among men aged 20 to 49 years, increased in women
Maintenance therapy with olaparib is associated with improved progression-free survival in metastatic pancreatic cancer patients with a germline BRCA1 and/or BRCA2 mutation

ASCO: Olaparib Beats Placebo for BRCA-Related Pancreatic Cancer

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Progression-free survival significantly improved with olaparib versus placebo for metastatic disease

May 2019 Briefing – Gastroenterology

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for May 2019. This roundup includes the latest...
For frail and elderly patients with advanced gastroesophageal cancer

ASCO: Low-Dose Chemo Benefits Advanced Gastroesophageal Cancer

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Elderly, frail receiving 60 percent of oxaliplatin/capecitabine dose have noninferior PFS, less toxicity
Pembrolizumab is noninferior to chemotherapy for overall survival among patients with programmed death ligand 1

ASCO: Pembrolizumab Noninferior to Chemo in Advanced Gastric Cancer

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For patients with PD-L1 combined positive score of ≥10, pembrolizumab prolongs overall survival
Providing assistance for physician impairment and rehabilitation is addressed in a position statement issued by the American College of Physicians and published online June 4 in the Annals of Internal Medicine.

ACP Issues Position on Response to Physician Impairment

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Rehabilitated doctors should be reintegrated into practice as long as patient safety not compromised
Clinical manifestations of systemic lupus erythematosus vary by racial and ethnic groups

Lupus Manifestations Appear to Differ by Race, Ethnicity

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Increased risk for severe manifestations seen among blacks, Hispanics, and Asians/Pacific Islanders
Taking proton pump inhibitors is associated with an excess of cause-specific mortality

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

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Excess mortality due to CVD, CKD, upper GI cancer for those with no indication for PPI use
High costs are associated with physician turnover and reduced clinical hours attributed to burnout

High Costs Associated With Physician Burnout in U.S.

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Nationally, about $4.6 billion in costs are related to physician turnover, reduced clinical hours
Whites in Western states are experiencing the most rapid increase in early-onset colorectal cancer

Early-Onset CRC Rising Fastest for Whites in Western States

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Neither increases in prevalence of obesity nor heavy alcohol consumption correlated with CRC trends