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The U.S. Food and Drug Administration has received reports of rare cases of worsening liver function or liver failure in patients with chronic hepatitis C virus who had moderate-to-severe liver impairment and were treated with Mavyret

FDA Reports Rare Cases of Liver Injury, Failure With Hep C Therapies

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Worsening liver functioning, liver failure reported among patients contraindicated for HCV therapies
For patients with advanced/metastatic colorectal cancer

Physical Activity, Overall Survival Not Linked in Metastatic CRC

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Nine or more MET hours per week tied to lower risk for grade ≥3 treatment-related adverse events
Use of dipeptidyl peptidase-4 inhibitors is associated with increased risks for pancreatitis and pancreatic cancer in patients with newly diagnosed type 2 diabetes

Dipeptidyl Peptidase-4 Inhibitors May Up Pancreatic Disease Risk

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Risks for pancreatitis, pancreatic cancer higher in Korean patients with newly diagnosed T2DM
The U.S. Preventive Services Task Force recommends hepatitis C virus infection screening for individuals aged 18 to 79 years. These recommendations form the basis of a draft recommendation statement published online Aug. 27 by the USPSTF.

USPSTF Advises Broader Age Range for Hep C Screening

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Draft recommendation statement expands screening to asymptomatic individuals aged 18 to 79 years
There is an increased risk for gallbladder- or biliary tract-related events among patients with type 2 diabetes taking liraglutide versus placebo

Liraglutide Ups Risk for Gallbladder, Biliary Tract Events

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Findings consistent for gallbladder stones, cholecystitis with/without gallbladder stones, biliary obstruction
Pregnancy alters the shape of the rectus abdominis muscle

Changes to Rectus Muscles From Pregnancy May Impact Abdominoplasty

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Rectus abdominis muscle changes may contribute to problems with abdominoplasty outcomes
The proportion of paracentesis and thoracentesis procedures performed by radiologists is continuing to increase

Radiologists Performing More Paracenteses, Thoracenteses

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2004 to 2016 saw increase in paracentesis, thoracentesis procedures performed by radiologists
The prevalence of celiac disease is higher among screened first-degree relatives of patients with celiac disease

Prevalence of Celiac Disease High in First-Degree Relatives

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FDRs with villous atrophy identified with high sensitivity and specificity by anti-TTG ≥2.75 of ULN
Patients with inflammatory bowel disease have an increased risk for type 2 diabetes

Type 2 Diabetes Risk Up With Inflammatory Bowel Disease

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Risk significantly higher for patients receiving diagnosis of IBD from 2003 through 2014 versus earlier
Older adults with cancer have increased odds of developing Clostridiodes difficile infection

Odds of Developing C. Diff Increased in Older Cancer Patients

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Risk for Clostridiodes difficile infection significantly greater with diagnosis of liquid tumors