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The excessive regulatory regime at the U.S. Food and Drug Administration is an important driver of high drug prices

Excessive FDA Regulation Driving High Drug Prices

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First-in-class drugs are fast-tracked while follow-on drugs can take up to 15 years to be approved
In individuals with type 1 diabetes

Parathyroid Hormone Linked to Arterial Stiffness in T1DM

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Significant association with carotid-femoral pulse wave velocity persists after multivariable adjustment
Diabetes-related end-stage renal disease among Native American adults fell by more than half over almost 20 years

CDC: Renal Failure From Diabetes Declining in Native Americans

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Diabetes-related kidney failure down by 54 percent over two decades
Smoking kills about six million people a year

Tobacco Control Plays Key Role in Saving Both Lives and Dollars

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Higher prices, taxes would deter smoking and generate income, WHO and others say
High-deductible health plans have multiplied in recent years

Many Families Find High Health Care Deductibles Burdensome

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Studies suggest significant out-of-pocket costs may harm low-income and chronically ill patients
A mathematical model can simulate hemoglobin A1c trajectories in type 2 diabetes mellitus models

Mathematical Model Can Simulate HbA1c Progression in T2DM

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Model represents alternative approach to simulate HbA1c trajectories vs. UK Prospective Diabetes Study
Enteroviruses may play a role in the development of at least some cases of type 1 diabetes

Enteroviruses May Be Linked to Autoimmunity Leading to T1DM

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Enteroviruses may induce an autoimmune process against insulin-producing cells in the pancreas
Resistance to the antilipolytic effect of insulin is increased in obese individuals with normal glucose tolerance

Adipose Tissue Insulin Resistance Up in Obese-NGT, IGT, T2DM

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Progressive decline in β-cell function linked to progressive impairment of free fatty acid suppression
The amplitude of therapeutic revascularization associated with recombinant adeno-associated virus (5 × 1012 viral particles encoding thymosin beta 4) is reduced with diabetes mellitus

Diabetes May Impair Myocardial Proangiogenic Response

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Reduction in amplitude of therapeutic neovascularization via rAAV.Tβ4 in pig model
N-acetylglucosamine/galactosamine is associated with insulin sensitivity

GlycA Linked to Insulin Sensitivity, Independent of CRP

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N-acetylglucosamine/galactosamine independently associated with insulin sensitivity index