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From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

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More than three-fold increase in percentage of adults using gabapentin and/or pregabalin
A long-term intensive lifestyle intervention in overweight and obese adults with type 2 diabetes mellitus is associated with greater cerebral blood flow

Intensive Lifestyle Intervention Linked to Cerebral Blood Flow

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In obese, overweight adults with T2DM, long-term weight loss intervention tied to greater blood flow
The cumulative risk of end-stage renal disease among patients with type 1 diabetes has declined over time in Finland

Risk of ESRD in T1DM Patients Has Fallen Markedly in Finland

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Relative risk of end-stage renal disease was 0.13 in those diagnosed in 1995-2011 versus 1965-1979
For community-dwelling older adults

Calcium, Vitamin D Don’t Seem to Reduce Fracture Risk in Seniors

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No reduction in incidence of fractures among community-dwelling older adults taking supplements
Extended-contact

Text Message Interventions May Help With Weight Management

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Interventions classified as effective were more likely to last longer than 12 weeks
The reduction in risk of cardiovascular death with empagliflozin is most mediated by changes in hematocrit and hemoglobin

Plasma Volume Changes May Mediate Effects of Empagliflozin

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Findings suggest reduced CV mortality risk mediated by effects on markers of plasma volume
Compared to placebo

Pioglitazone Associated With Lower Blood Leptin in Diabetes

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In T2DM, leptin levels are lower with pioglitazone than placebo but not oral antidiabetic drugs
From 2015 to 2016

CDC: 2015 to 2016 Saw Drop in Life Expectancy in United States

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Increase in rate of age-adjusted drug overdose deaths observed during same time period
Established bone fragility variants are associated with a concordant phenotypic model of the pediatric skeleton but not with discordant phenotypic models

Bone Fragility Variants Linked to Concordant Pediatric Skeleton

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Novel loci identified for discordant multi-dimensional skeletal phenotypes
For healthy adults and individuals with well-controlled type 2 diabetes

DPP-4 Inhibitor Has Dissociated Effects on β-Cell Function

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Single dose of sitagliptin linked to increases in standardized insulin secretion, active GIP, GLP-1