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Rare variants have been identified in the DENND1A gene that are associated with hormonal traits of polycystic ovary syndrome

Rare Variants Identified in DENND1A Gene in PCOS

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Variants are associated with reproductive and metabolic traits in PCOS families
Overall

Events for Living Kidney Donors Mainly Occur After Two Years

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Overall, 90.2 percent of the events that took place two or more years after donation were nonsurgical
Structured support for patients transitioning from pediatric to adult care for type 1 diabetes may improve outcomes

Transition Support Program May Aid Young Adults With Type 1 Diabetes

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However, benefits were not sustained 12 months after completion of the intervention
Patients with type 2 diabetes who receive intensive treatment to keep their blood pressure levels at 130/80 mm Hg or below experience fewer heart attacks

Intensive Blood Pressure Therapy Aids Patients With T2DM

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Overall death from any cause reduced, regardless of cardiovascular risk
Ambiguous genitalia in newborns may be more common than previously thought

Ambiguous Genitalia in Newborns Not Uncommon

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Ratio of prematurity, small for gestational age higher in newborns with disorders of sex development
The addition of liraglutide to metformin is effective and safe for children and adolescents with type 2 diabetes

Liraglutide Added to Metformin Effective for Type 2 Diabetes

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Trial shows superiority of liraglutide with respect to glycemic control in children, adolescents
The risk for adverse drug reactions may be higher for women

Gender Differences Seen in Adverse Drug Reactions

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Differences found in reaction symptoms and types of drugs tied to adverse reactions
Substituting red meat with high-quality plant protein sources

Swapping Red Meat for Plant-Based Proteins May Cut CVD Risk

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Switching to plant proteins rather than fish, carbs leads to bigger improvements in lipids, lipoproteins
In patients with type 1 diabetes

Dapagliflozin Improves Glucose Outcomes in Type 1 Diabetes

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Benefits observed without increase in time spent in hypoglycemic range
More than half of Medicare beneficiaries initiating dialysis die within one year

Over Half of Seniors Initiating Dialysis Die Within One Year

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Higher one-year mortality tied to activity-of-daily-living dependence, age ≥85, at least four comorbidities