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Lowering of plasma uric acid with febuxostat is associated with a modest reduction in systolic blood pressure in patients with type 1 diabetes mellitus

Plasma Uric Acid Lowering Tied to Drop in Systolic BP in T1DM

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Febuxostat has modest BP-lowering effect, with no impact on arterial stiffness, urinary nitric oxide
Molecular autopsy for electrical disorder and cardiomyopathy genes identifies a modest but realistic yield in sudden arrhythmic death syndrome

Molecular Autopsy IDs Causes of Sudden Arrhythmic Death

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Researchers identified clinically actionable rare variants in 13 percent of SADS cases
Low sodium intake is not associated with a reduction in blood pressure in the long term

Evidence Suggests Sodium Guidelines Are Misguided

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Dietary sodium intake inversely associated with systolic, diastolic blood pressure in long term

T2DM Risk Cut by Variant in Sulfonylurea Receptor Encoder

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Missense variant in ABCC8 gene also linked to reduced risk of coronary heart disease
Central obesity is associated with increased risk of mortality even in normal-weight individuals

Central Obesity Ups Mortality Across BMI Range

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Increased mortality with central obesity for normal-weight, overweight, obese individuals
Consuming excess choline raises levels of the bacteria-produced compound trimethylamine N-oxide and increases the tendency of platelets to clump together and form clots

Gut Bacteria May Convert Choline Into Clot-Enhancing Compound

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Significant increase in plasma TMAO levels at one and two months; increase attenuated by aspirin
Use of the History

Use of HEART Score Has Limited Impact for Chest Pain in ER

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Using score during assessment of patients with chest pain in emergency department deemed safe
Peak postoperative high-sensitivity troponin T is associated with increased risk of 30-day mortality among patients undergoing noncardiac surgery

Post-Op hsTnT Linked to 30-Day Mortality After Noncardiac Sx

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Increased risk of 30-day mortality for absolute high-sensitivity troponin T change of 5ng/L or higher
Biking to work may help lengthen lifespan

Cycling To and From Work Linked Lower CVD, Mortality Risk

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In five-year study, cyclists saw risk for heart disease, cancer, early death cut by almost half
Markers of microvascular endothelial dysfunction can predict dementia

Microvascular Endothelial Dysfunction Can Predict Dementia

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Midregional pro-atrial natriuretic peptide is predictor of all-cause and vascular dementia