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Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors

Measuring Plasma PCSK9 May ID Resistance to PCSK9 Inhibitors

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Most patients experience increase of at least 3.7-fold in plasma PCSK9 levels after treatment
The Value-Based Payment Modifier is not associated with performance differences between practices serving higher-risk and lower-risk patients

Value-Based Payment Modifier Not Tied to Practice Performance

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Performance differences between practices narrowed after adjustment for patient characteristics
Clinician denial of some types of tests requested by patients is associated with worse patient satisfaction with the clinician

Clinician Denial of Patient Requests Impacts Satisfaction

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Worse satisfaction in association with denial of request for referral, pain meds, other meds, lab tests
Cardiovascular disease hospitalization rates have declined in recent years among individuals with and those without diabetes

1998 to 2014 Saw Drop in CVD Hospitalization Rates in Diabetes

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Rates of CVD hospitalizations remained two to four times higher for those with versus without diabetes
For patients with atrial fibrillation and prior cerebrovascular accident

Ablation Cuts Risk of Recurrent Stroke in Patients With A-Fib

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Patients with AF with no ablation have increased five-year risk of CVA, death versus ablated patients
Heart rate variability and specific inflammatory biomarkers can differentiate major depressive disorder from depression in bipolar disorder

Simple ECG May Help Distinguish MDD From Bipolar Depression

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Higher low-frequency heart rate variability, lower levels of IL-10 and MCP-1 for major depression
Clinician suspicion has minimal accuracy for the diagnosis of Lyme disease

Clinician Suspicion Minimally Accurate for Lyme Disease

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12 percent of the children clinicians thought were unlikely to have Lyme disease had Lyme disease
Coffee consumption seems safe and is associated with reduced risk for various health outcomes

Coffee Consumption Appears to Provide More Benefit Than Harm

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Largest relative reduction in health outcomes seen with intake of three to four cups/day versus none
Percutaneous transluminal angioplasty seems to be safe but ineffective for patients with multiple sclerosis and chronic cerebrospinal venous insufficiency

Percutaneous Transluminal Angioplasty Ineffective in MS

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Findings in patients with relapsing-remitting MS and chronic cerebrospinal venous insufficiency
New solutions are needed to address burnout among health care team members

New Workflows Have Potential to Address Provider Burnout

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Change fatigue is the leading cause of care team burnout, yet new solutions needed