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Naturally occurring monoclonal antibodies show potential for treatment of neurologic diseases

Naturally Occurring Antibodies Promising for Neurologic Disease

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Successful phase 1 clinical trial without toxic effects for one such molecule, HIgM22
Use of antibiotics in patients with heart failure exacerbation in the absence of compelling evidence of infection is unnecessary and potentially harmful

Harms From Unnecessary Abx Extend Beyond Resistance

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Case highlights importance of carefully monitoring patients with prolonged QT interval
Pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio may be predictors for survival in nasopharyngeal carcinoma

Hematologic Markers Predict Nasopharyngeal Cancer Survival

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High neutrophil-lymphocyte, platelet-lymphocyte ratios tied to shorter survival
Functional magnetic resonance imaging might someday help psychiatrists quickly determine which antipsychotic drugs work best for patients with schizophrenia or bipolar disorder

fMRI May Take Guesswork Out of Schizophrenia Rx

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Personalized approach could eliminate trial-and-error, hasten critical time to treatment
As monotherapy

Leukotriene Receptor Antagonist Monotherapy Ups Asthma Control

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Random effects meta-analysis shows reduced risk of exacerbation with LTRA monotherapy
The U.S. Preventive Services Task Force recommends that clinicians ask adults

USPSTF Urges Doctors to Ask Adults About Tobacco Use

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Clinicians should offer interventions to help adults, including pregnant women, stop smoking
The risk of developing diabetes is higher in younger adults versus middle-aged adults despite the same duration and degree of weight gain

T2DM Risk With Weight Gain Higher in Younger Adults

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Relative risk for same level of weight gain greater in younger adults than in middle-aged adults
Atrial fibrillation is associated with increased risk of dementia

Atrial Fibrillation Linked to Increased Risk of Dementia

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Association strongest for younger participants and for those with longest duration of AF
U.S. children with a genetic polymorphism affecting FUT2 secretor status appear to be protected from severe rotavirus gastroenteritis

Rotavirus Gastroenteritis Almost Absent in FUT2 Nonsecretors

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U.S. children with genetic polymorphism affecting secretor status seem to be protected from rotavirus
The Pioneer accountable care organization program correlated with reductions in low-value services during its first year

Accountable Care Organizations Can Cut Low-Value Service Use

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Greater reductions with higher than markets' mean baseline levels of low-value service use