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In a letter to the editor published online March 24 in Clinical & Experimental Ophthalmology

Reactivation of HSV Described in Patient After Cataract Surgery

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Herpes simplex uveitis ID'd as cause of persistently elevated intraocular pressure after cataract sx
For patients with type 2 diabetes newly treated with antidiabetic drugs

Pioglitazone Linked to Increased Risk of Bladder Cancer

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Duration- and dose-response associations for pioglitazone; no correlation for rosiglitazone
The American College of Cardiology and the American Heart Association Task Force on Clinical Practice Guidelines has updated the recommendations regarding duration of dual antiplatelet therapy for patients with coronary artery disease. The updated practice guideline was published online March 29 in the Journal of the American College of Cardiology.

Guidelines Updated on Duration of Dual Antiplatelet Tx in CAD

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Longer-duration tx represents trade-off between decreased risk of cardiac events, increased bleeding
Neuronal heparan sulfates modulate brain amyloid-β clearance and aggregation in a mouse model of Alzheimer's disease

Neuronal Heparan Sulfates Play Role in Amyloid Pathology

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Removal of neuronal HS linked to reduction in Aβ oligomerization and deposition of amyloid plaques
Baricitinib

Baricitinib Superior to Placebo in Refractory Rheumatoid Arthritis

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Findings based on patients with previous inadequate response to biologics
Oral estradiol therapy is associated with less progression of subclinical atherosclerosis in postmenopausal women when therapy is initiated early in menopause

Early Menopause Estradiol Tx Cuts Atherosclerosis Advance

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Positive effect seen only on carotid-artery intima-media thickness
Use of nonoperative management of rectal cancer is increasing

Non-Surgical Management of Rectal Cancer Increasing

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But, findings show use more likely in black, uninsured, and Medicaid patients
Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria symptoms and angioedema unresponsive to high doses of antihistamine treatment

Omalizumab Effective for Chronic Spontaneous Urticaria

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Treatment improves quality of life, cuts angioedema recurrence
A long-acting formulation of the integrase inhibitor raltegravir can protect humanized bone marrow-liver-thymus mice from high-dose vaginal HIV challenges

Long-Acting Raltegravir Shows Promise in Protection from HIV

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Long-acting formulation protects humanized mice from repeated high-dose vaginal HIV challenges
Defitelio (defibrotide sodium) has been approved by the U.S. Food and Drug Administration to treat a rare

FDA Approves First Tx for Disease Linked to Stem Cell Transplant

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Hepatic veno-occlusive disease is rare, but fatal