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A new two-step Ebola vaccine strategy has shown some promise in early clinical trials

Early Trials Offer Promising Results for 2-Step Ebola Vaccine

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One vaccine provided first as a primer, and the second given as a booster
Metformin is associated with reduced cardiovascular mortality compared with sulfonylureas

Lower CVD Mortality for Metformin Versus Sulfonylureas

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Large analysis found up to 40 percent lower risk of heart disease mortality versus sulfonylureas
The first case of Alzheimer's disease (AD) diagnosed in a person with HIV suggests progressive dementia in older HIV+ individuals may be due to HIV-associated neurocognitive disorder

Novel Case of Alzheimer’s Reported in HIV+ Patient

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Amyloid PET imaging may help distinguish AD from HIV-associated neurocognitive disorder
Implantation of sliding growth guidance instrumentation LSZ-4D

Metal Up in Blood With Titanium Growth Guidance Sliding Device

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Increased content of metal ion in blood and tissue around implanted device in children with scoliosis
Many breast cancer patients receive chemotherapy they don't need

AACR: Many Breast Cancer Patients May Not Need Chemo

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Genetic test can help doctors determine who can safely avoid treatment after surgery
For perimenopausal and postmenopausal women

Review: Paroxetine Reduces Vasomotor Symptoms

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Moderate quality evidence shows reduction in frequency of hot flashes with paroxetine
For renal transplant recipients

Oral Nicotinamide Safe for Renal Transplant Recipients

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Treatment linked to nonsignificant reductions in new non-melanoma skin cancers
For patients with post-myocardial infarction heart failure

Mineralocorticoid Receptor Antagonists No Benefit Post MI

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MRA in addition to standard therapy does not improve outcome in setting of post-MI heart failure
Network meta-analysis

Network Meta-Analysis Recommends Prostaglandins for Glaucoma

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Highest-ranking class for reducing intraocular pressure was prostaglandins for 1999, 2004, 2009
Two- and four-hour mixed-meal tolerance tests vary for C-peptide responses in type 1 diabetes

Mixed-Meal Tolerance Tests Vary for C-Peptide Response in T1DM

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Variation in the percent of the total four-hour C-peptide AUC captured in first two hours