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A U.S. Food and Drug Administration advisory panel vote on whether to recommend approval of the first oral medication for type 1 diabetes ended in an 8-8 tie Thursday.

FDA Panel Has Tie Vote on New Type 1 Diabetes Drug

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Zynquista is a once-daily pill meant to help type 1 diabetes patients manage their blood glucose levels
The U.S. Food and Drug Administration alerted health care providers on Thursday that the agency is investigating the use of paclitaxel-coated balloons and paclitaxel-eluting stents to treat peripheral arterial disease in the femoropopliteal artery because of a potentially increased mortality risk in the long term.

FDA Investigating Paclitaxel-Coated Balloons, Paclitaxel-Eluting Stents

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Investigation triggered by meta-analysis showing possible increased mortality in PAD patients at 2 years
Frailty and Alzheimer disease-related brain changes independently contribute to dementia status

Frailty Could Increase Susceptibility for Dementia

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Authors say frailty should be considered in clinical care, management of Alzheimer dementia
Trained alert dogs can help patients with type 1 diabetes regulate their blood glucose levels

Trained Alert Dogs Can Detect Impending T1DM-Related Events

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In study, individual dogs' performance varied for detecting hypoglycemic episodes, hyperglycemia
For asymptomatic patients with stable ischemic heart disease and coronary artery disease

Variation in Revascularization for Asymptomatic SIHD Unexplained

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Consistent benefit observed for patients with stable ischemic heart disease managed by revascularization
Less than half of all outpatient antibiotic prescription fills by privately insured nonelderly adults and children in the United States are appropriate or potentially appropriate

Inappropriate Antibiotic Rx Common in Privately Insured

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Only 12.8 and 35.5 percent of fills were appropriate, potentially appropriate in outpatients
Use of the oral hepatoselective glucokinase activator TTP399 for type 2 diabetes does not cause hypoglycemia and has no detrimental effect on plasma lipids or liver enzymes

Oral Hepatoselective Glucokinase Activator Promising in T2DM

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Clinically significant and sustained reduction in glycated hemoglobin was observed with TTP399
U.S. states with more physicians and a larger percentage of non-Hispanic whites have worse melanoma survival

Melanoma Survival Varies Among U.S. States

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Worse survival in states with more physicians; higher death rates in states with lower incidence
Mandated neonatal abstinence syndrome surveillance and reporting allows state health departments to quantify incidence and informs programs and services

Mandated Neonatal Abstinence Reporting Helps Quantify Cases

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Five of six states with mandatory reporting receive case reports within 30 days of diagnosis
Radiographic knee osteoarthritis is associated with an increased risk for mortality from cardiovascular disease

Radiographic Knee Osteoarthritis Tied to Increased Risk for Death

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Risk higher for cardiovascular disease, diabetes, renal mortality; lower risk for cancer mortality