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Taking proton pump inhibitors is associated with an excess of cause-specific mortality

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

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Excess mortality due to CVD, CKD, upper GI cancer for those with no indication for PPI use
The International Pediatric Multiple Sclerosis Study Group has updated standards for future clinical trials in pediatric multiple sclerosis; the new recommendations were published in the May 28 issue of Neurology.

Recommendations Developed for Pediatric Multiple Sclerosis Trials

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Biological rationale exists for using treatments proven efficacious in adults with MS for pediatric MS
The rate of emergency department visits with opioids only given during the visit is higher than the rate for visits with opioids only prescribed at discharge and for visits with opioids given and prescribed

More Opioids Given Than Prescribed in Emergency Department

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Opioids more often given in ED than prescribed at discharge for adult ED visits
Clinical manifestations of systemic lupus erythematosus vary by racial and ethnic groups

Lupus Manifestations Appear to Differ by Race, Ethnicity

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Increased risk for severe manifestations seen among blacks, Hispanics, and Asians/Pacific Islanders
Esketamine nasal spray plus an oral antidepressant appears to be a safe and effective treatment for patients with treatment-resistant depression

Esketamine Nasal Spray May Improve Refractory Depression Outcomes

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Findings seen among outpatients with treatment-resistant depression using combo nasal spray, oral antidepressant
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB
Less than 60 percent of prescriptions for the treatment of sexually transmitted infections among teens seeking care in the emergency department are filled

Noncompliance Common in Teens Prescribed STI Treatment in ED

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Prescriptions often go unfilled; hospital admission is the only factor associated with prescription filling
Exercise and/or behavioral treatment interventions may provide clinically meaningful improvements in depression outcomes in adults with type 2 diabetes and major depressive disorder

Exercise, Therapy May Improve Depression, Diabetes Outcomes

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Exercise and cognitive behavioral therapy can improve depression outcomes in adults with type 2 diabetes
Clinical guidelines on adjuvant and salvage radiotherapy after radical prostatectomy have been updated

Guidelines Updated for Radiotherapy After Prostatectomy

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Updates include adjuvant radiotherapy for patients with adverse pathologic findings, hormonal therapies
The first test to detect the Zika virus in human blood has been approved by the U.S. Food and Drug Administration.

FDA Approves First Test for Zika in Human Blood

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The ZIKV Detect 2.0 IgM Capture ELISA is made by Seattle-based InBios