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AMD Predicts Poorer Survival in Older Women

In women older than 80 years, early AMD linked to all-cause and non-CVD, non-cancer mortality

FRIDAY, May 29, 2015 (HealthDay News) — Age-related macular degeneration (AMD) predicts poorer survival, especially among women aged 80 years or older, according to a study published in the May issue of the Journal of the American Geriatrics Society.

Kathryn L. Pedula, from the Kaiser Permanente Center for Health Research in Portland, Ore., and colleagues examined the correlation between AMD and mortality in older women. Data were included for 1,202 women with graded fundus photographs at the Year 10 visit of the Study of Osteoporotic Fractures.

The researchers found that the prevalence of any AMD was 40.5 percent at baseline (36.7 percent early AMD and 3.8 percent late AMD). Over 15 years of follow-up, cumulative mortality was 51.6 percent. There was no significant correlation between AMD presence or severity and all-cause or cause-specific mortality. Analyses were stratified according to age group because there was a significant correlation between AMD and age in predicting mortality. In women younger than 80 years, late AMD correlated with cardiovascular disease (CVD) mortality (hazard ratio, 2.61) after adjustment for covariates. In women aged 80 years and older, early AMD correlated with all-cause and non-CVD, non-cancer mortality (hazard ratios, 1.39 and 1.45, respectively), while any AMD correlated with all-cause and CVD mortality (hazard ratios, 1.42 and 1.45, respectively).

“These results suggest that AMD may serve as a useful prognostic indicator for women who may benefit from risk factor modification, particularly those aged 80 and older,” the authors write.

One author disclosed financial ties to Merck Sharp & Dohme.

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