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Monthly Archives: October 2019

After one year of therapy with lumacaftor-ivacaftor in a real-world setting

Lumacaftor-Ivacaftor Aids Cystic Fibrosis in Real-World Setting

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Improved lung function, increased BMI, reduced need for IV antibiotics seen after one year of therapy
Public insurance

Barriers to Timely Access to Pediatric Hearing Aids Identified

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Severity of hearing loss lessens time from testing to ordering of hearing aids
Very low or very high weight gains during twin pregnancies are associated with adverse birth outcomes

Too Much, Too Little Weight Gain May Harm Twin Pregnancies

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Study informs guidance for ranges of safe, unsafe weight gain in twin pregnancies
Poor glycemic control is associated with increased risks for stroke and death among patients with type 2 diabetes

Poor Glycemic Control May Up Risk for Stroke, Death in T2DM

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Risk for stroke, death increased with each 10 mmol/mol increase in HbA1c level
Reduction in peripapillary retinal nerve fiber layer thickness is significantly associated with physical and cognitive disability in patients with multiple sclerosis

Retinal Nerve Fiber Loss Linked to Disability in Multiple Sclerosis

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Reductions in thickness significantly associated with physical, cognitive disability
A drop in household income over six years is associated with a higher risk for subsequent incident cardiovascular disease during the next 17 years

Changes in Household Income Tied to Cardiovascular Disease Risk

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Drop in income linked to higher risk for incident disease, while increase in income lowers risk
Clinical recommendations for the prevention of secondary fractures among older adults with hip or vertebral fracture have been issued by a multi-stakeholder coalition assembled by the American Society for Bone and Mineral Research and published online Sept. 20 in the Journal of Bone and Mineral Research.

Recommendations Developed for Preventing Secondary Fractures

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Coalition reaches consensus on guidance for patients 65 years and older with hip or vertebral fracture
Ibrutinib is associated with an increased risk for new or worsened hypertension in patients treated for B-cell malignancies

Ibrutinib Therapy Linked to New, Worsened Hypertension

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Ibrutinib-related hypertension associated with increased risk for major adverse cardiovascular events
Most dimensions of quality of life (QoL) are impaired in patients with relapsed/refractory multiple myeloma

Effects on Quality of Life Mixed for Tx of Multiple Myeloma

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Reduced pain but worsening of neuropathy seen for IxaThalDex induction tx in relapsed/refractory MM
Seasonal influenza viruses are circulating widely in the Southern Hemisphere

CDC: Seasonal Influenza Viruses Circulating in Southern Hemisphere

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Influenza A(H3) predominating in many regions in Southern Hemisphere; influenza activity low in U.S.