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Monthly Archives: June 2019

The incidence of infection increases with glucocorticoid dose for patients with polymyalgia rheumatica or giant cell arteritis

Oral Steroids Increase Infection Risk in Inflammatory Disease

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Dose-response effect seen with increased infection risk even at low daily doses of oral glucocorticoids
Transfusion dose density is an independent prognostic factor for progression-free survival in patients with myelodysplastic syndromes treated with red blood cell transfusions

Transfusion Dose Density Affects Myelodysplastic Syndrome Survival

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Negative effect of transfusion treatment on PFS occurs at density less than 3 units/16 weeks
Infants who are given acid suppression therapy in their first year of life are more likely to subsequently break a bone

Antacid Use in First Year of Life Tied to Later Fracture Risk

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Findings seen among healthy infants taking proton pump inhibitors alone or with histamine H2-receptor antagonists
More than 2 percent of suicides among adults 55 years and older are associated with patients living in or transitioning to long-term care

Suicide Risk Seen Among Older Adults Living in Long-Term Care

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Mental health and well-being of older adults should be addressed in these settings, authors say
The decline in midlife ischemic strokes over time is less pronounced than the decline among older adults

Greater Long-Term Decline in Stroke Seen Among Older Adults

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Continued focus on prevention efforts needed to lower risk for midlife ischemic strokes
Treatment with a combination of alpelisib and fulvestrant prolongs progression-free survival among patients with PIK3CA-mutated

Drug Combo Slows Progression in Advanced Breast Cancer

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Results seen for alpelisib plus fulvestrant in PIK3CA-mutated, HR+, HER2− advanced breast cancer
Vyleesi (bremelanotide) has been approved to treat acquired

Vyleesi Approved for Hypoactive Sexual Desire Disorder in Women

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FDA approved Vyleesi for premenopausal women; drug administered by subcutaneous injection
Self-reported poor oral health is not associated with gastrointestinal cancer risk

Poor Oral Health Not Linked to Gastrointestinal Cancer Risk

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In site-specific analyses, significant correlation seen for poor oral health with hepatocellular carcinoma
Older individuals who develop cancer have better memory and slower memory decline than those who remain cancer-free

Seniors Who Develop Cancer Have Better Memory, Slower Decline

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Rate of memory decline 3.9 percent slower in those with, versus those without, cancer diagnosis
The indication for a cystic fibrosis treatment

FDA Expands Cystic Fibrosis Treatment Approval to Children Ages 6 to 12

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Symdeko previously approved for patients ≥12 years with cystic fibrosis and certain genetic mutations