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Yearly Archives: 2017

Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors

Measuring Plasma PCSK9 May ID Resistance to PCSK9 Inhibitors

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Most patients experience increase of at least 3.7-fold in plasma PCSK9 levels after treatment
The prevalence of arthritis in the United States seems to have been underestimated

Prevalence of Arthritis Underestimated in United States

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Arthritis affected 91.2 million adults in 2015, including 61.1 million aged 18 to 64 years in 2015
There has been a recent escalation in the incidence of scarlet fever in England

Escalation Noted in Incidence of Scarlet Fever in England

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Three-fold increase in rates between 2013 and 2014, with further increases in 2015, 2016
A workgroup from the Joint Task Force on Practice Parameters has reviewed evidence and provided guidance for health care providers regarding treatment of seasonal allergic rhinitis in patients aged 12 years or older. The clinical guideline was published online Nov. 28 in the Annals of Internal Medicine.

Guidance Issued for Seasonal Allergic Rhinitis Pharmacologic Tx

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Recommendation for monotherapy with intranasal corticosteroid over intranasal corticosteroid combo
Biennial biopsies are an acceptable alternative to annual biopsies for men managing low-risk prostate cancer through active surveillance

Less Frequent Biopsy May Be Option in Prostate Cancer Care

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Consequences of biennial versus annual biopsies similar during active surveillance
Heart rate variability and specific inflammatory biomarkers can differentiate major depressive disorder from depression in bipolar disorder

Simple ECG May Help Distinguish MDD From Bipolar Depression

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Higher low-frequency heart rate variability, lower levels of IL-10 and MCP-1 for major depression
For reversal of opioid overdose

Similar Efficacy for Intranasal, Intramuscular Naloxone

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Similar efficacy for higher-concentration intranasal naloxone, IM naloxone administered at same dose
The five-year risks of cervical intraepithelial neoplasia grade 3 (CIN3)

Risk of ≥CIN3 Drops With Negative HPV, Cytology Co-Tests

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Decrease in 5-year ≥CIN3 risks after each successive negative round of HPV, cytology co-testing
For infants with bronchiolitis

Practice Variation in Treatment for Bronchiolitis in Infants

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Variation in evidence-based supportive therapies by site, ranging from 6 to 99 percent
For patients with atrial fibrillation and prior cerebrovascular accident

Ablation Cuts Risk of Recurrent Stroke in Patients With A-Fib

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Patients with AF with no ablation have increased five-year risk of CVA, death versus ablated patients