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Monthly Archives: November 2017

Zelboraf (vemurafenib) has been approved by the U.S. Food and Drug Administration as the first drug to treat certain adults patients with Erdheim-Chester disease.

Zelboraf Approved for Use in Erdheim-Chester Disease

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Kinase inhibitor (vemurafenib) for use in patients with BRAF V600 mutation
Alcohol use is associated with certain types of cancer

ASCO Issues Statement Regarding Alcohol and Cancer

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Alcohol-related cancers account for 5.5 percent of all cancers treated annually worldwide
For patients with acute severe bleeding

Delay in Tranexamic Acid Administration Reduces Benefit

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Survival benefit decreases by 10 percent for every 15-minute delay in treatment for severe bleeding
Differences in glycosylation between H3N2 egg-adapted vaccines and circulating strains probably reduced vaccine effectiveness during the 2016-2017 influenza season

Glycosylation Differences in Egg-Adapted Vaccines May Cut Impact

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H3N2 egg-adapted vaccines, circulating strains were different in 2016-2017 influenza season
For patients with Parkinson's disease and excessive daytime sleepiness

Sodium Oxybate Promising for Parkinson’s, Daytime Sleepiness

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Improvements in subjective sleep quality, objectively measured slow-wave sleep duration
There has been little change in the treatment recommendations for cough due to the common cold since publication of guidelines in 2006

Evidence Scant for Treatment of Cough With the Common Cold

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Update recommends against nonsteroidal anti-inflammatory agents for adults, codeine for children
Factors including increases in health care service price and intensity are associated with increases in U.S. health care spending from 1996 to 2013

Increases in U.S. Health Spending Tied to Health Service Price

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Higher spending also linked to population growth and aging, negatively linked to disease incidence
For patients presenting to the emergency department with acute extremity pain

In ER, Combination of Ibuprofen, Acetaminophen Relieves Pain

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No difference in pain reduction for ibuprofen and acetaminophen vs. 3 opioid/acetaminophen combos
For patients with inflammatory bowel disease

Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD

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Risk higher for those exposed to combination therapy versus thiopurine or anti-TNF monotherapy
The incidence of end-stage renal disease with diabetes listed as the primary cause decreased across the United States from 2000 to 2014

Drop in Incidence of End-Stage Renal Disease Due to Diabetes

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2000 to 2014 saw decrease in incidence of ESRD with diabetes listed as the primary cause