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Monthly Archives: October 2017

Treatment with long-acting muscarinic antagonists plus long-acting β-agonists is associated with fewer exacerbation events in patients with chronic obstructive pulmonary disease

LAMA Plus LABA Tied to Fewer Exacerbations in Stable COPD

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Also might result in greater improvement in FEV1 than LABA plus corticosteroids
An analysis of whole-exome and RNA sequencing data reveals mutations

Insulinomas May Hold Key to Diabetes Drug Development

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Novel discovery of molecular pathways may reveal map to regenerate insulin-producing cells
Many basic scientists and clinical researchers support somatic genome editing in adults for prevention of serious disease but not for human enhancement; they also believe the public should be consulted before any clinical application of germline gene editing proceeds

Scientists Support Genome Editing to Prevent Disease

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Majority of survey respondents support gene editing to treat diseases but not human enhancement
Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs

Commercialization of Generics Impacts Adverse Event Rates

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Adverse events up for generic users of losartan, valsartan, candesartan in month of commercialization
For patients with acute heart failure admitted to the emergency department

ER Risk Score Predicts 30-Day Mortality in Acute Heart Failure

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Risk score based on 13 independent risk factors has excellent discrimination and calibration
Small molecular medicines can be printed precisely using organic vapor jets

Process Promising for On-Site Printing of Custom-Dosed Meds

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Printed films, original powders exhibit similar crystallographic order and chemistry
General practitioners are less likely to support cessation of smoking in patients with cancer than in those with coronary heart disease

Smoking Cessation Support Less Likely for Cancer Patients

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General practitioners less likely to support smoking cessation in patients with cancer than with CHD
Overall breast cancer incidence rates increased among specific racial/ethnic groups from 2005 to 2014

Overall Breast Cancer Incidence Up for Some in 2005-2014

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Incidence up for Asian/Pacific Islanders, non-Hispanic blacks, Hispanics, not non-Hispanic whites
While measles incidence is extremely low in the United States

More U.S. Measles Cases From No Vaccine vs. Imported Disease

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Failure to vaccinate, rather than vaccine performance, appears to be driving transmission
For patients with suspected coronary artery disease

MI Incidence Down With CT Angiography in Suspected CAD

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But no reduction in mortality, cardiac hospitalizations for CCTA versus functional stress testing