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Monthly Archives: August 2017

Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval

Studies Used for FDA Approval of Device Changes Often Low Quality

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And, efficacy of drugs granted accelerated approval often confirmed only years after approval
For adults with type 2 diabetes diagnosed for less than 10 years

Lifestyle Intervention Only Offers Modest Benefit in Type 2 Diabetes

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Change in glycemic control did not reach criterion for equivalence among adults diagnosed for <10 years
Adoption of specialty access standards has not improved access to specialists

Specialist Access No Better With Adoption of Access Standards

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No notable improvement in timely access to specialty services following implementation of standards
There is a strong relationship between high on-clopidogrel platelet reactivity and two-year ischemic and bleeding outcomes after drug-eluting stent implantation

High Platelet Reactivity Tied to Ischemic, Bleeding Outcomes

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Findings based on two-year follow-up after drug-eluting stent implantation
The order of successive office hysteroscopy and endometrial biopsy for evaluation of abnormal uterine bleeding does not impact the global pain perception or time required

Hysteroscopy, Endometrial Biopsy Order Has No Effect on Pain

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Order of successive office procedures for evaluation of uterine bleeding has no effect on pain.
Compared to patients themselves

Caregivers Have a Worse View of Cancer Patients’ Functional Status

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Patient-caregiver assessments of patient function, mental health, social support differ significantly
Intraindividual variability of reaction time is independently associated with mortality

Intraindividual Variability in Reaction Time Tied to Mortality

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Independent link identified, which changed very little after excluding incident dementia cases
Fecal calprotectin adds most to discrimination between pediatric patients with and without inflammatory bowel disease

Fecal Calprotectin Is Best Marker for Discriminating Pediatric IBD

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Blood markers, fecal calprotectin aid discrimination between pediatric patients with, without IBD
Zika virus infection is associated with increased incidence of neurological syndromes

Diverse Spectrum of Neurologic Syndromes Seen With Zika

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Increase in admissions for Guillain-Barré syndrome, encephalitis compared with before outbreak
There is an inverse correlation between sleep duration and risk markers of type 2 diabetes in childhood

Sleep Duration Inversely Linked to Risk Markers of T2DM in Kids

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Strong inverse correlations between sleep duration, adiposity, diabetes risk markers in children