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Monthly Archives: June 2017

Cirrhosis may raise an older person's odds for a stroke

Stroke Risk Elevated in Elderly Patients With Cirrhosis

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Magnitude of association higher for intracerebral, subarachnoid hemorrhage versus ischemic stroke
Two new medications that target specific genetic mutations may improve survival for patients with specific types of advanced non-small-cell lung cancer

ASCO: Novel Meds Show Promise in Advanced NSCLC

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Results presented from two phase III trials
Nearly one in six Americans taking non-vitamin K antagonist oral anticoagulants for atrial fibrillation may not be receiving the proper dose

Many Taking NOACs for A-Fib May Not Be Getting Right Dose

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Study of newer medications finds 16 percent receive too much or too little
Small unruptured intracranial aneurysms have low growth and rupture rates

Small Unruptured Intracranial Aneurysms Grow Slowly

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Low growth and rupture rates for aneurysms which are ≤3 mm, ≤5 mm, and ≤7 mm
From 2013 to 2015 there was a decrease in additional surgery after initial lumpectomy

ASCO: Recent Drop in Additional Surgery Post Lumpectomy

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Decrease was concomitant with 2014 consensus statement endorsing a margin of no ink on tumor
There is little agreement between the American Society of Clinical Oncology Value Framework and European Society for Medical Oncology Magnitude of Clinical Benefit Scale

ASCO: Agreement Lacking With ESMO on Most Effective Drugs

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Negative correlation identified for ASCO benefit score with monthly incremental drug costs
Depression treatment with venlafaxine is associated with increased levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen

Venlafaxine Use Linked to Bone Turnover Markers in Older Adults

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Increase in CTX and decrease in P1NP, consistent with accelerated bone loss with antidepressant tx
From 2004 to 2015 there were decreases in the prevalence of advanced disease at initiation of antiretroviral therapy in 10 high-burden countries

Prevalence of Advanced HIV at ART Initiation Decreasing

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Decreases seen in Haiti, Mozambique, Namibia, Nigeria, Swaziland, Uganda, Vietnam, Zimbabwe
Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions

Positive Clinical Effects Seen for Placebos Without Deception

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Findings based on five studies involving patients with IBS, depression, allergic rhinitis, back pain, ADHD
For children

Lower HbA1c Linked to Better Diabetes-Specific HRQoL in Youth

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Three diabetes management behaviors were significantly correlated with D-HRQoL