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Monthly Archives: April 2016

The offspring of women using ondansetron early in pregnancy for nausea and vomiting of pregnancy or hyperemesis gravidarum may be at risk for cardiac abnormalities

Review: Low Risk of Birth Defects With Ondansetron Exposure

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Ondansetron-exposed neonates may have small increase in incidence of cardiac abnormalities
Blockade of histamine 1 and 4 receptors in peanut challenge can combine to prevent development of intestinal allergic responses

Histamine Receptor Blockade Stops Peanut-Induced Response

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Histamine 1 and 4 receptors involved in intestinal allergic responses in mouse model of peanut allergy
For older adults starting antimuscarinic treatment for overactive bladder

Potentially Inappropriate Meds Use Common With OAB Tx

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For older adults initiating antimuscarinic medication for overactive bladder, PIM is prevalent
Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits

Doctors Can Be Misled About FDA ‘Breakthrough’ Drug Designation

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Many believe meds supported by stronger evidence than the law requires to achieve designation
Older men who receive androgen deprivation therapy for prostate cancer may be at increased risk of developing depression

Androgen Deprivation Tx for Prostate CA Tied to Depression

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Researchers find 23 percent increased risk compared to men who received other treatments
Parental hip fracture is independently associated with increased risk of offspring major osteoporotic fracture and hip fracture

Parental Hip Fracture Independently Ups Offspring Risk

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Strength of correlation decreases with older parental age at hip fracture
A quality improvement intervention does not reduce in-hospital mortality for critically ill patients treated in intensive care units

Quality Improvement Process Doesn’t Cut ICU Mortality

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No reduction in in-hospital mortality for critically ill patients from ICUs in Brazil
There are no significant differences in occurrence of cardiovascular disease tied to treatment with glucagon-like peptide-1 receptor agonists compared with dipeptidyl peptidase-4 inhibitors

CV Risk Not Significantly Different for GLP-1 Receptor Agonists

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Findings based on large study in real-world, head-to-head comparison of other drugs
There has been an increase in the number of patients being treated for Galactose-alpha-1

Increase in Number of Patients Being Treated for Alpha-Gal

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Increase attributed to improved understanding of presentation, and improved diagnostic testing
Recommendations have been developed to increase human papillomavirus vaccine uptake

ASCO Presents Guidelines for Increasing HPV Vaccine Uptake

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Oncologists should raise awareness of HPV-related cancers and role of vaccinations