15 percent relative reduction in the median Framingham CVD risk following eight weeks of time-restricted eating intervention
THURSDAY, May 19, 2022 (HealthDay News) — Time-restricted eating (TRE), limiting energy intake to eight hours followed by fasting for 16 hours (16:8 TRE), is associated with a reduction in cardiovascular disease (CVD) risk among older breast cancer survivors (BCS), according to a research letter published online May 17 in JACC: CardioOncology.
Amy A. Kirkham, Ph.D., from the University of Toronto, and colleagues conducted a single-arm feasibility study to examine adherence, safety, and preliminary efficacy of eight weeks of 16:8 TRE on CVD risk among 22 BCS (aged 60 years and older).
Participants adhered to â¥16-hours of fasting for a median of 98 percent of prescribed days. The researchers found that calorie intake changed by a median of â450 kcal, representing a 22 percent relative reduction. There was no change noted in fat-free mass. At eight weeks, the median Framingham CVD risk decreased from 10.9 to 8.6 percent (â15 percent relative change). No significant change was seen in the modifiable Framingham components overall. Decreases were seen in mean magnetic resonance imaging-derived visceral adipose tissue, bioelectrical impedance analysis-derived whole-body fat mass, and body mass. At baseline, 15 of the participants were classified as cardiometabolically unhealthy; eight of the 15 (53 percent) no longer met the criteria for pharmacologic treatment of CVD risk or metabolic syndrome following the eight-week intervention.
“Our preliminary efficacy findings include a 2 percent absolute or 15 percent relative CVD risk reduction within just eight weeks among BCS at risk for CVD mortality due to overweight/obese status, older age, and receipt of anthracyclines,” the authors write.
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