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An estimated 12.6 million persons in the United States could benefit from treatment to prevent active tuberculosis

12.6 Million in U.S. Could Benefit From Tx to Prevent Active TB

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Revised NHANES-based estimate for prevalence of latent TB infection excludes those who report prior tx
Overall tuberculosis rates are low among children and adolescents and are declining steadily

Tuberculosis Rates for U.S. Children Are Low and Declining

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Disparities persist by race, ethnicity, geography; incidence higher for those living in U.S.-affiliated islands
Guidelines have been updated for screening and treatment for tuberculosis infection among health care personnel

Recs Updated for TB Screening, Treatment in Health Care Workers

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Guidelines include preplacement TB risk assessment, postexposure symptom evaluation and testing
In 2017

CDC: TB Incidence Declined Slightly in United States in 2017

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Number of cases, disease incidence decreased globally, but more progress needed to meet targets
For HIV-infected patients

One-Month Regimen Noninferior for Preventing HIV-Related TB

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One-month rifapentine, isoniazid noninferior to nine months of isoniazid alone
A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides

Short Regimen Noninferior for Rifampin-Resistant Tuberculosis

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Short regimen of nine to 11 months noninferior to 20-month regimen following WHO guidelines
Stratifying tuberculosis patients by disease severity may enable shorter treatment regimens

Stratifying by Severity May Allow Shorter TB Tx Regimens

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Those with minimal disease may be cured with a four-month versus six-month treatment regimen
The frequency of relapse-free cure from multidrug-resistant tuberculosis is higher than previously anticipated

Relapse-Free Cure From MDR-TB Higher Than Anticipated

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Per simplified outcome definition, frequency similar in low-, intermediate-, high-incidence countries
In pretreatment isolates of Mycobacterium tuberculosis

MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse

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Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk
In children with latent tuberculosis

Rifampin Effective for Latent Tuberculosis in Children

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Rifampin has advantage of being a shorter, single-drug regimen that is palatable for children