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Hydrocortisone Plus Fludrocortisone Superior for Septic Shock

Compared with hydrocortisone alone, combo significantly cuts risk for in-hospital death or hospice discharge

Azithromycin Cuts Maternal Sepsis, Death in Vaginal Delivery

For women planning vaginal delivery, azithromycin linked to lower risk for maternal sepsis or death

Cardiovascular Hospitalization Increased After Sepsis Hospitalization

Patients discharged after sepsis hospitalization have increased risk for all-cause mortality, all-cause rehospitalization

Restrictive, Liberal Fluid Strategies Yield Similar Outcomes for Sepsis-Induced Hypotension

All-cause death before discharge home by day 90 occurred in 14.0 percent of the restrictive fluid group and 14.9 percent in the liberal fluid group

Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies

Performance of lumbar puncture has decreased in late-onset sepsis evaluations; 16 percent of late-onset meningitis cases occurred without late-onset sepsis

7.7 Million Deaths Associated With 33 Bacterial Pathogens in 2019

Deaths associated with these pathogens comprised 13.6 percent of all global deaths, 56.2 percent of all sepsis-related deaths

AI Algorithm May ID Dysfunctional Immune Profiles in Acute Infection

Machine learning framework used to deploy quantitative sepsis response signature score, which was estimated using seven- or 12-gene signature

Pediatric Sepsis Survivors May Face New, Progressing Comorbidities

Nearly one in five have new or worsening medical condition versus nonsepsis critical care survivors

Early Warning System Can Identify Sepsis Patients

Patients whose alert was confirmed by provider within three hours had reduced in-hospital mortality rate

IV Vitamin C Increases Risk for Death, Organ Failure in Sepsis

Risk increased with intravenous vitamin C versus placebo for adults with sepsis in the ICU receiving vasopressor therapy