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Patients with psoriasis may have a slightly increased risk for cancer

Psoriasis Linked to Increased Risk for Developing Cancer

Increased risk particularly seen with keratinocyte cancer and lymphomas
Four drugs have similar Psoriasis Area and Severity Index response rates for both short- and long-term treatment of plaque psoriasis

Several Drugs Have Similar Efficacy for Plaque Psoriasis

Findings based on meta-analysis of data for short- and long-term efficacy from 60 clinical trials
Biologics seem to be associated with greater reduction in psoriasis severity scores and higher drug survival rates than methotrexate in pediatric patients treated in a real-world setting

Biologics Tied to Greater Reduction in Pediatric Psoriasis

However, methotrexate remains an effective treatment for pediatric psoriasis
Prenatal tobacco exposure is associated with an increased risk for pediatric psoriasis

Prenatal Tobacco Exposure May Raise Risk for Pediatric Psoriasis

Exposure-response relationship observed for increasing quantities of cigarettes smoked daily
Obesity does not necessarily induce or contribute to familial psoriasis

Familial Psoriasis May Not Be Tied to Obesity

Patients with familial psoriasis were younger, had a lower BMI at diagnosis versus nonfamilial psoriasis
While the rate of thyroid dysfunction among patients with psoriasis generally is not higher than expected

Inflammation Linked to Thyroid Dysfunction in Psoriasis Patients

Patients with thyroid dysfunction and psoriasis have higher serum C-reactive protein levels
Rates of type 2 diabetes may be higher among patients with psoriasis

Type 2 Diabetes More Common in Patients With Psoriasis

Association between psoriasis and metabolic syndrome differs by sex
Co-occurring psoriasis is common among patients with palmoplantar pustulosis

Palmoplantar Pustulosis Confirmed as Orphan Disease

However, psoriasis frequently co-occurs in patients with palmoplantar pustulosis
The five-year incidence rate of joint surgery in psoriatic arthritis patients is twice as high as in the general population

Rates of Joint Surgery Higher With Psoriatic Arthritis

After 15 years of follow-up, 29 percent of psoriatic arthritis patients had received surgery
For patients with psoriatic arthritis

ACR: Age at Psoriasis Onset Sets Course for Psoriatic Arthritis

Pustular psoriasis linked to arthritis onset two years earlier; increased delay seen for plaque psoriasis